methyl 2-((2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)propanate

Base Information

Chemical Name:methyl 2-((2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)propanate
CAS No.:1373398-45-8
Molecular Formula:C₃₃H₃₀N₂O₃
Molecular Weight:502.613
Hs Code.:

Synonyms:methyl 2-((2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)propanate

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Chemical Property of methyl 2-((2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)propanate

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Technology Process of methyl 2-((2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)propanate

There total 6 articles about methyl 2-((2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)propanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 710354-39-5
2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)biphenyl-3-ol

: 5445-17-0
Methyl 2-bromopropionate

: 1373398-45-8
methyl 2-((2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)propanate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1248/cpb.60.164

Reference yield:

: 451-40-1
phenyl benzyl ketone

: 1373398-45-8
methyl 2-((2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)propanate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium acetate / ethanol / 20 h / Inert atmosphere; Reflux

2.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 3.08 h / 20 - 60 °C / Inert atmosphere

2.2: 3 h / 35 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 16 h / 20 - 50 °C / Inert atmosphere

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydroxide / ethanol; water / 15 h / Reflux; Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium acetate; sodium hydride; potassium carbonate; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; ethanol; water; N,N-dimethyl-formamide; mineral oil; 4.1: Suzuki coupling;
DOI:10.1248/cpb.60.164

Reference yield:

: 945242-95-5,300658-40-6
(E)-1-(2-bromophenyl)-2-(1,2-diphenylethylidene)hydrazine

: 1373398-45-8
methyl 2-((2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)propanate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 3.08 h / 20 - 60 °C / Inert atmosphere

1.2: 3 h / 35 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 16 h / 20 - 50 °C / Inert atmosphere

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydroxide / ethanol; water / 15 h / Reflux; Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; potassium carbonate; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; ethanol; water; N,N-dimethyl-formamide; mineral oil; 3.1: Suzuki coupling;
DOI:10.1248/cpb.60.164