1-<2-Benzyloxy-4-(4-hydroxymethylphenoxy)phenyl>-2-<5-benzyloxy-2-(2-hydroxymethyl-4-methoxyphenyl)phenyl>-ethane

Base Information

Chemical Name:1-<2-Benzyloxy-4-(4-hydroxymethylphenoxy)phenyl>-2-<5-benzyloxy-2-(2-hydroxymethyl-4-methoxyphenyl)phenyl>-ethane
CAS No.:139963-05-6
Molecular Formula:C₄₃H₄₀O₆
Molecular Weight:652.787
Hs Code.:

Synonyms:1-<2-Benzyloxy-4-(4-hydroxymethylphenoxy)phenyl>-2-<5-benzyloxy-2-(2-hydroxymethyl-4-methoxyphenyl)phenyl>-ethane

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Chemical Property of 1-<2-Benzyloxy-4-(4-hydroxymethylphenoxy)phenyl>-2-<5-benzyloxy-2-(2-hydroxymethyl-4-methoxyphenyl)phenyl>-ethane

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Technology Process of 1-<2-Benzyloxy-4-(4-hydroxymethylphenoxy)phenyl>-2-<5-benzyloxy-2-(2-hydroxymethyl-4-methoxyphenyl)phenyl>-ethane

There total 6 articles about 1-<2-Benzyloxy-4-(4-hydroxymethylphenoxy)phenyl>-2-<5-benzyloxy-2-(2-hydroxymethyl-4-methoxyphenyl)phenyl>-ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 139963-04-5
1-<2-Benzyloxy-4-(4-methoxycarbonylphenoxy)phenyl>-2-<5-benzyloxy-2-(2-methoxycarbonyl-4-methoxyphenyl)phenyl>-ethane

: 139963-05-6
1-<2-Benzyloxy-4-(4-hydroxymethylphenoxy)phenyl>-2-<5-benzyloxy-2-(2-hydroxymethyl-4-methoxyphenyl)phenyl>-ethane

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 2.5h;
DOI:10.1016/S0040-4020(01)88193-X

Reference yield:

: 35450-36-3
methyl 2-bromo-5-methoxybenzoate

: 139963-05-6
1-<2-Benzyloxy-4-(4-hydroxymethylphenoxy)phenyl>-2-<5-benzyloxy-2-(2-hydroxymethyl-4-methoxyphenyl)phenyl>-ethane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) (Ph₃P)4Pd, 2.) aq. NaHCO₃ / 1.) DME, 20 min, 2.) 1 h, reflux

2: 85 percent / NaOMe / methanol / 8 h

3: 98 percent / H₂ / Pd/C / ethanol; ethyl acetate

4: 83 percent / K₂CO₃, KI / acetone / 3 h / Heating

5: 70 percent / LiAlH₄ / diethyl ether / 2.5 h / 0 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium methylate; sodium hydrogencarbonate; potassium carbonate; potassium iodide; palladium on activated charcoal; In methanol; diethyl ether; ethanol; ethyl acetate; acetone;
DOI:10.1016/S0040-4020(01)88193-X

Reference yield:

: 139962-97-3
3-Benzyloxy-6-boronobenzaldehyde diethyl acetal

: 139963-05-6
1-<2-Benzyloxy-4-(4-hydroxymethylphenoxy)phenyl>-2-<5-benzyloxy-2-(2-hydroxymethyl-4-methoxyphenyl)phenyl>-ethane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) (Ph₃P)4Pd, 2.) aq. NaHCO₃ / 1.) DME, 20 min, 2.) 1 h, reflux

2: 85 percent / NaOMe / methanol / 8 h

3: 98 percent / H₂ / Pd/C / ethanol; ethyl acetate

4: 83 percent / K₂CO₃, KI / acetone / 3 h / Heating

5: 70 percent / LiAlH₄ / diethyl ether / 2.5 h / 0 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium methylate; sodium hydrogencarbonate; potassium carbonate; potassium iodide; palladium on activated charcoal; In methanol; diethyl ether; ethanol; ethyl acetate; acetone;
DOI:10.1016/S0040-4020(01)88193-X