(R)-2-(5-bromo-7-methylquinolin-6-yl)-2-hydroxyethyl 4-methylbenzenesulfonate

Base Information

Chemical Name:(R)-2-(5-bromo-7-methylquinolin-6-yl)-2-hydroxyethyl 4-methylbenzenesulfonate
CAS No.:1447016-99-0
Molecular Formula:C₁₉H₁₈BrNO₄S
Molecular Weight:436.326
Hs Code.:

Synonyms:(R)-2-(5-bromo-7-methylquinolin-6-yl)-2-hydroxyethyl 4-methylbenzenesulfonate

Suppliers and Price of (R)-2-(5-bromo-7-methylquinolin-6-yl)-2-hydroxyethyl 4-methylbenzenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(5-bromo-7-methylquinolin-6-yl)-2-hydroxyethyl 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:

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Technology Process of (R)-2-(5-bromo-7-methylquinolin-6-yl)-2-hydroxyethyl 4-methylbenzenesulfonate

There total 8 articles about (R)-2-(5-bromo-7-methylquinolin-6-yl)-2-hydroxyethyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1447016-98-9
(R)-1-(5-bromo-7-methylquinolin-6-yl)ethane-1,2-diol

: 98-59-9
p-toluenesulfonyl chloride

: 1447016-99-0
(R)-2-(5-bromo-7-methylquinolin-6-yl)-2-hydroxyethyl 4-methylbenzenesulfonate

Guidance literature:: With di(n-butyl)tin oxide; triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 136-90-3
4-methoxy-3-methylaniline

: 1447016-99-0
(R)-2-(5-bromo-7-methylquinolin-6-yl)-2-hydroxyethyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid; 3-Nitrobenzenesulfonic acid; boric acid; ferrous(II) sulfate heptahydrate / 1 h / 140 °C

2.1: sulfuric acid; N-Bromosuccinimide / 3.5 h / 15 °C

3.1: boron tribromide / dichloromethane / 3 h

3.2: 12 h / pH 12

4.1: pyridine / dichloromethane / 2 h / -30 - 0 °C

5.1: lithium chloride; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C

6.1: AD mix-β / water; tert-butyl alcohol / 48 h / 0 °C

7.1: triethylamine; di(n-butyl)tin oxide / dichloromethane / 0 - 20 °C

With pyridine; ferrous(II) sulfate heptahydrate; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; AD mix-β; sulfuric acid; boric acid; boron tribromide; di(n-butyl)tin oxide; triethylamine; 3-Nitrobenzenesulfonic acid; lithium chloride; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 50741-92-9
2-methyl-4-nitroanisole

: 1447016-99-0
(R)-2-(5-bromo-7-methylquinolin-6-yl)-2-hydroxyethyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen; palladium 10% on activated carbon / ethanol; ethyl acetate / 24 h / 760.05 Torr

2.1: sulfuric acid; 3-Nitrobenzenesulfonic acid; boric acid; ferrous(II) sulfate heptahydrate / 1 h / 140 °C

3.1: sulfuric acid; N-Bromosuccinimide / 3.5 h / 15 °C

4.1: boron tribromide / dichloromethane / 3 h

4.2: 12 h / pH 12

5.1: pyridine / dichloromethane / 2 h / -30 - 0 °C

6.1: lithium chloride; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C

7.1: AD mix-β / water; tert-butyl alcohol / 48 h / 0 °C

8.1: triethylamine; di(n-butyl)tin oxide / dichloromethane / 0 - 20 °C

With pyridine; ferrous(II) sulfate heptahydrate; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; AD mix-β; sulfuric acid; palladium 10% on activated carbon; hydrogen; boric acid; boron tribromide; di(n-butyl)tin oxide; triethylamine; 3-Nitrobenzenesulfonic acid; lithium chloride; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;