Thioacetic acid S-{(2R,3S)-2,3-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-pentyl} ester

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Chemical Name:Thioacetic acid S-{(2R,3S)-2,3-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-pentyl} ester
CAS No.:104946-97-6
Molecular Formula:C₃₁H₅₀O₃SSi₂
Molecular Weight:558.973
Hs Code.:

Synonyms:Thioacetic acid S-{(2R,3S)-2,3-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-pentyl} ester

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Chemical Property of Thioacetic acid S-{(2R,3S)-2,3-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-pentyl} ester

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Technology Process of Thioacetic acid S-{(2R,3S)-2,3-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-pentyl} ester

There total 5 articles about Thioacetic acid S-{(2R,3S)-2,3-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-pentyl} ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 104946-96-5
(2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>-1-pentanol

: 507-09-5
tiolacetic acid

: 104946-97-6
Thioacetic acid S-{(2R,3S)-2,3-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-pentyl} ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 5h;
DOI:10.1021/jm00384a026

Reference yield:

: 4390-94-7
1,2-bis(4-methoxyphenyl)butanone

: 104946-97-6
Thioacetic acid S-{(2R,3S)-2,3-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-pentyl} ester

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / NaH, EtSH / dimethylformamide / 19 h / 120 °C

2: 89 percent / imidazole / dimethylformamide / 1 h

3: diethyl ether; hexane / 20 h / Ambient temperature

4: 1.) BH₃*THF, 2.) H₂O, NaOH, H₂O₂ / 1.) THF, 0 deg C, 4.5 h, 2.) THF, from 45 to 50 deg C, 1 h

5: 76 percent / Ph₃P, diisopropyl azodicarboxylate / tetrahydrofuran / 5 h / 0 °C

With 1H-imidazole; sodium hydroxide; borane-THF; di-isopropyl azodicarboxylate; water; dihydrogen peroxide; sodium hydride; triphenylphosphine; ethanethiol; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00384a026

Reference yield:

: 76579-69-6
1,2-bis-(4-hydroxy-phenyl)-butan-1-one

: 104946-97-6
Thioacetic acid S-{(2R,3S)-2,3-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-pentyl} ester

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / imidazole / dimethylformamide / 1 h

2: diethyl ether; hexane / 20 h / Ambient temperature

3: 1.) BH₃*THF, 2.) H₂O, NaOH, H₂O₂ / 1.) THF, 0 deg C, 4.5 h, 2.) THF, from 45 to 50 deg C, 1 h

4: 76 percent / Ph₃P, diisopropyl azodicarboxylate / tetrahydrofuran / 5 h / 0 °C

With 1H-imidazole; sodium hydroxide; borane-THF; di-isopropyl azodicarboxylate; water; dihydrogen peroxide; triphenylphosphine; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00384a026