(R)-3-((R)-2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoyl)-4-isopropyl oxazolidin-2-one

Base Information

Chemical Name:(R)-3-((R)-2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoyl)-4-isopropyl oxazolidin-2-one
CAS No.:1262547-43-2
Molecular Formula:C₂₉H₃₁N₃O₆
Molecular Weight:517.582
Hs Code.:

Synonyms:(R)-3-((R)-2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoyl)-4-isopropyl oxazolidin-2-one

Suppliers and Price of (R)-3-((R)-2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoyl)-4-isopropyl oxazolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-3-((R)-2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoyl)-4-isopropyl oxazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-3-((R)-2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoyl)-4-isopropyl oxazolidin-2-one

There total 16 articles about (R)-3-((R)-2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoyl)-4-isopropyl oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1262547-41-0
(R)-4-isopropyl-3-(3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoyl)oxazolidin-2-one

: 1262547-43-2
(R)-3-((R)-2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoyl)-4-isopropyl oxazolidin-2-one

Guidance literature:: (R)-4-isopropyl-3-(3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoyl)oxazolidin-2-one; With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 1h;

With N-(benzenesulfonyl)-3-phenyloxaziridine; In tetrahydrofuran; at -78 ℃; for 4h;
DOI:10.1016/j.ejmech.2011.05.028

Reference yield:

: 501031-61-4
2-(5-methyl-2-phenyloxazol-4-yl)acetaldehyde

: 1262547-43-2
(R)-3-((R)-2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoyl)-4-isopropyl oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / -10 °C

1.2: 0.17 h / -10 °C

2.1: platinum(IV) oxide trihydrate; hydrogen / methanol / 12 h / 760.05 Torr

3.1: lithium hydroxide monohydrate / ethanol / 1 h / 20 °C

3.2: pH 3

4.1: triethylamine / tetrahydrofuran / 0.5 h / -78 - 0 °C

5.1: n-butyllithium / tetrahydrofuran; hexane

5.2: 0.5 h / -78 - 20 °C

6.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

6.2: 4 h / -78 °C

With n-butyllithium; lithium hydroxide monohydrate; platinum(IV) oxide trihydrate; potassium tert-butylate; hydrogen; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; methanol; ethanol; hexane; 1.2: Horner-Wadsworth-Emmons olefination / 6.2: Davis asymmetric oxidation;
DOI:10.1016/j.ejmech.2011.05.028

Reference yield:

: 1262547-37-4
methyl 3-(2-(chloromethyl)benzo[d]oxazol-5-yl)propanoate

: 1262547-43-2
(R)-3-((R)-2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoyl)-4-isopropyl oxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide / 3 h / 150 °C

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / -10 °C

2.2: 0.17 h / -10 °C

3.1: platinum(IV) oxide trihydrate; hydrogen / methanol / 12 h / 760.05 Torr

4.1: lithium hydroxide monohydrate / ethanol / 1 h / 20 °C

4.2: pH 3

5.1: triethylamine / tetrahydrofuran / 0.5 h / -78 - 0 °C

6.1: n-butyllithium / tetrahydrofuran; hexane

6.2: 0.5 h / -78 - 20 °C

7.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

7.2: 4 h / -78 °C

With n-butyllithium; lithium hydroxide monohydrate; platinum(IV) oxide trihydrate; potassium tert-butylate; hydrogen; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; methanol; ethanol; hexane; N,N-dimethyl-formamide; 2.2: Horner-Wadsworth-Emmons olefination / 7.2: Davis asymmetric oxidation;
DOI:10.1016/j.ejmech.2011.05.028