1289646-72-5

Basic information

• Product Name: C₂₈H₂₃Cl₂N
• Synonyms: C₂₈H₂₃Cl₂N
• CAS NO: 1289646-72-5
• Molecular Weight: 444.403
• Mol File: 1289646-72-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₈H₂₃Cl₂N(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₂₃Cl₂N(1289646-72-5)
• EPA Substance Registry System: C₂₈H₂₃Cl₂N(1289646-72-5)

Safety Data

• Hazardous Substances Data: 1289646-72-5(Hazardous Substances Data)

Usage

General Description

The chemical compound C28H23Cl2N is a chlorinated derivative of diphenylamine. It is a white crystalline solid that appears as a yellow powder, commonly used as a stabilizer in the production of plastics and rubber products. Its molecular formula indicates the presence of 28 carbon atoms, 23 hydrogen atoms, 2 chlorine atoms, and 1 nitrogen atom in its structure. C₂₈H₂₃Cl₂N has a molecular weight of approximately 455.40 g/mol. It is important to handle this substance with care, as it can be harmful if ingested or inhaled, and can cause irritation to the skin and eyes upon contact.

Upstream product

• 73075-58-8 5,7-dichloro isoquinoline 
• 1000210-73-0 (3,5-dichloro-benzylidene)-(2,2-diethoxy-ethyl)-amine 
• 76-83-5 trityl chloride 
• 73075-47-5 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline hydrochloride 
• 89315-56-0 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline 
• 10203-08-4 3,5-dichlorobenzaldehyde 
• 14046-52-7 N-(2-chloroethyl)-3,5-dichlorobenzylamine hydrochloride 

Downstream Products

• 1194550-63-4 C₄₆H₄₀Cl₂N₂O₅S 
• 1194550-65-6 benzyl (S)-2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-[3-(methylsulfonyl)phenyl]propanoate hydrochloride 
• 1194550-67-8 ((S)-benzyl 2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-methylsulfonyl)phenyl)propanoate 
• 1025967-78-5 (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid 
• 1194550-56-5 5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 
• 1289646-93-0 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid hydrochloride 
• 851784-82-2 2-(tert-butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 

Relevant articles and documents

Discovery and development of potent LFA-1/ICAM-1 antagonist SAR 1118 as an ophthalmic solution for treating dry eye

LFA-1/ICAM-1 interaction is essential in support of inflammatory and specific T-cell regulated immune responses by mediating cell adhesion, leukocyte extravasation, migration, antigen presentation, formation of immunological synapse, and augmentation of T-cell receptor signaling. The increase of ICAM-1 expression levels in conjunctival epithelial cells and acinar cells was observed in animal models and patients diagnosed with dry eye. Therefore, it has been hypothesized that small molecule LFA-1/ICAM-1 antagonists could be an effective topical treatment for dry eye. In this letter, we describe the discovery of a potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonist (SAR 1118) and its development as an ophthalmic solution for treating dry eye.