4-OXO-3,4-DIHYDROQUINAZOLINE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 4-OXO-3,4-DIHYDROQUINAZOLINE-2-CARBOXYLIC ACID
• CAS No.: 29113-34-6
• Molecular Formula: C9H6 N2 O3
• Molecular Weight: 190.158
• Hs Code.: 2933998090
• Mol file: 29113-34-6.mol

Synonyms:2-Quinazolinecarboxylicacid, 1,4-dihydro-4-oxo- (9CI); 3,4-Dihydro-4-oxoquinazoline-2-carboxylic acid;4-Oxo-3,4-dihydroquinazoline-2-carboxylic acid; NSC 159703

Chemical Property of 4-OXO-3,4-DIHYDROQUINAZOLINE-2-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 4.5E-08mmHg at 25°C
• Melting Point: 215-216 °C (decomp)
• Boiling Point: 427.6°C at 760 mmHg
• PKA: 3.99±0.20(Predicted)
• Flash Point: 212.4°C
• PSA: 83.05000
• Density: 1.56g/cm³
• LogP: 0.62130

Purity/Quality:

97% ^*data from raw suppliers

4-Oxo-3,4-dihydroquinazoline-2-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-OXO-3,4-DIHYDROQUINAZOLINE-2-CARBOXYLIC ACID

There total 9 articles about 4-OXO-3,4-DIHYDROQUINAZOLINE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethyl 4-oxo-3,4-dihydro-2-quinazolinecarboxylate (29113-33-5) → 3,4-dihydro-4-oxoquinazoline-2-carboxylic acid (29113-34-6)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 2.5h;

DOI:10.3797/scipharm.aut-00-25

Reference yield: 77.0%

ethyl bromoacetate (105-36-2) + anthranilic acid amide (28144-70-9,88-68-6) → 3,4-dihydro-4-oxoquinazoline-2-carboxylic acid (29113-34-6)

Guidance literature:

With potassium carbonate; copper(I) bromide; In dimethyl sulfoxide; at 120 ℃; for 24h;

DOI:10.1055/s-0033-1340040

Reference yield:

anthranilic acid amide (28144-70-9,88-68-6) → 3,4-dihydro-4-oxoquinazoline-2-carboxylic acid (29113-34-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / 5 h / 185 - 186 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; H₂O / 0.33 h / 20 °C

With lithium hydroxide; In tetrahydrofuran; water;

DOI:10.1021/jo070837d

upstream raw materials:

4-oxo-3,4-dihydroquinazoline-2-carbonitrile

(2-cyano-phenyl)-oxalamic acid

ethyl 4-oxo-3,4-dihydro-2-quinazolinecarboxylate

anthranilic acid amide

Downstream raw materials:

4-Hydroxyquinazoline

4-oxo-N-phenyl-3,4-dihydroquinazoline-2-carboxamide

tryptanthrine

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