91526-18-0

Basic information

• Product Name: 4-(hidroximetil)-5-metil-1,3-dioxol-2-ona
• Synonyms: 1,3-Dioxol-2-one, 4-(hydroxymethyl)-5-methyl-;4-(hidroximetil)-5-metil-1,3-dioxol-2-ona;4-(hydroxymethyl)-5-methyl-l,3-dioxol-2-one;4-(HydroxyMethyl)-5-Methyl-[1,3]dioxol-2-one;4-(hidroxiMetil)-5-Metil-1,3-dioxol-2-one;DMDO-OH;4-Methyl-5-hydroxyMethyl-2-oxo-1,3-dioxol-4-ene;AZATMint-D
• CAS NO: 91526-18-0
• Molecular Formula: C₅H₆O₄
• Molecular Weight: 130.1
• EINECS: 1308068-626-2
• Mol File: 91526-18-0.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 214℃
• Flash Point: 93℃
• Appearance: /
• Density: 1.367
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 14.54±0.10(Predicted)
• CAS DataBase Reference: 4-(hidroximetil)-5-metil-1,3-dioxol-2-ona(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(hidroximetil)-5-metil-1,3-dioxol-2-ona(91526-18-0)
• EPA Substance Registry System: 4-(hidroximetil)-5-metil-1,3-dioxol-2-ona(91526-18-0)

Safety Data

• Hazardous Substances Data: 91526-18-0(Hazardous Substances Data)

Usage

Description

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a reagent used in organic synthesis, particularly for the introduction of the non-chiral (oxodioxolenyl)methyl carbamate group to active pharmaceutical ingredients (APIs) to afford the corresponding pro-drug.

Uses

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is used in preparation method of key intermediate of olmesartan medoxomil.

Upstream product

• 80841-78-7 4-chloromethyl-5-methyl-1,3-dioxol-2-one 
• 80715-22-6 4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one 
• 37830-90-3 4,5-Dimethyl-1,3-dioxole-2-one 
• 91526-17-9 4-formyloxymethyl-5-methyl-1,3-dioxolen-2-one 

Downstream Products

• 863031-21-4 Azilsartan medoxomil 
• 912357-50-7 (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-cyclopropyl-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate 
• 1121795-67-2 S-ethyl O-((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl) carbonothioate 
• 1159501-38-8 4-((R)-3-(bis(5-methyl-2-oxo-[1,3]dioxol-4-ylmethoxy)phosphoryl)-2-((6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl)amino)propionyl)piperazine-1-carboxylic acid butyl ester 
• 1309361-34-9 (2S)-2-(5-methyl-1,3-dioxol-2-one-4-ylmethylamino)-2-phenyl-n-butyl-3,4,5-trimethoxybenzoate 
• 1417575-99-5 (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester of 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid dimethylacetamide 

Relevant articles and documents

AN IMPROVED PROCESS FOR 4-(HYDROXYMETHYL)-5-METHYL-1,3-DIOXOL-2-ONE

The present invention relates to an improved process for 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one (I). The process involves reaction of compound of formula (II) with sodium acetate in presence of catalytic amount of potassium iodide in dimethyl formamide solvent at 25-30°C to give 5-methyl-2-oxo-1,3-dioxol-4-yl)methyl acetate (IV) which was further Acid hydrolysed by IPA. HCl in Isopropyl alcohol solvent to yield 4-(hydroxymethyl)-5-methyl-1,3-dioxol-2-one (I).

Preparation method of olmesartan medoxomil key intermediate

The invention discloses a preparation method of an olmesartan medoxomil key intermediate, and belongs to the technical field of medicine synthesis. The key points of the technical scheme are as follows: triphosgene with relatively low toxicity is adopted to replace gaseous phosgene, so that the problems of storage and transportation are solved; and a molecular distillation technology is utilized to treat the crude product, so that the occurrence of a polymer at high temperature is avoided, and a high-yield product is obtained.

Tetrahydrocyclopentapyrrole derivative and preparation method therefor

The purpose of the present invention is to provide: a tetrahydrocyclopentapyrrole derivative capable of being used for preventing or treating a peptic ulcer gastritis or reflux esophagitis; a preparation method therefor; and a pharmaceutical composition containing the same.