[2-(4-Hexyloxy-2,5-diiodo-phenoxy)-ethyl]-methyl-{4-[(E)-2-(4-nitro-phenyl)-vinyl]-phenyl}-amine

Base Information

• Chemical Name: [2-(4-Hexyloxy-2,5-diiodo-phenoxy)-ethyl]-methyl-{4-[(E)-2-(4-nitro-phenyl)-vinyl]-phenyl}-amine
• CAS No.: 637036-63-6
• Molecular Formula: C₂₉H₃₂I₂N₂O₄
• Molecular Weight: 726.393
• Mol file: 637036-63-6.mol

Synonyms:[2-(4-Hexyloxy-2,5-diiodo-phenoxy)-ethyl]-methyl-{4-[(E)-2-(4-nitro-phenyl)-vinyl]-phenyl}-amine

Chemical Property of [2-(4-Hexyloxy-2,5-diiodo-phenoxy)-ethyl]-methyl-{4-[(E)-2-(4-nitro-phenyl)-vinyl]-phenyl}-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(4-Hexyloxy-2,5-diiodo-phenoxy)-ethyl]-methyl-{4-[(E)-2-(4-nitro-phenyl)-vinyl]-phenyl}-amine

There total 3 articles about [2-(4-Hexyloxy-2,5-diiodo-phenoxy)-ethyl]-methyl-{4-[(E)-2-(4-nitro-phenyl)-vinyl]-phenyl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-(hexyloxy)-2,5-diiodophenol (357396-86-2) + 4-(N-(2-hydroxyethyl)-N-methylamino)-4′-nitrostilbene (122008-76-8) → [2-(4-Hexyloxy-2,5-diiodo-phenoxy)-ethyl]-methyl-{4-[(E)-2-(4-nitro-phenyl)-vinyl]-phenyl}-amine (637036-63-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 48h;

DOI:10.1039/b208190c

Reference yield:

1,4-diiodo-2,5-dimethoxybenzene (51560-21-5) → [2-(4-Hexyloxy-2,5-diiodo-phenoxy)-ethyl]-methyl-{4-[(E)-2-(4-nitro-phenyl)-vinyl]-phenyl}-amine (637036-63-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / BBr₃ / CH₂Cl₂ / 5 h / -78 - 20 °C

2: 56 percent / KOH / dimethylsulfoxide / 20 h / 20 °C

3: 79 percent / DEAD; Ph₃P / tetrahydrofuran / 48 h / 20 °C

With potassium hydroxide; boron tribromide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 3: Mitsunobu reaction;

DOI:10.1039/b208190c

Reference yield:

2,5-diiodo-1,4-hydroquinone (13064-64-7) → [2-(4-Hexyloxy-2,5-diiodo-phenoxy)-ethyl]-methyl-{4-[(E)-2-(4-nitro-phenyl)-vinyl]-phenyl}-amine (637036-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / KOH / dimethylsulfoxide / 20 h / 20 °C

2: 79 percent / DEAD; Ph₃P / tetrahydrofuran / 48 h / 20 °C

With potassium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dimethyl sulfoxide; 2: Mitsunobu reaction;

DOI:10.1039/b208190c

upstream raw materials:

4-(hexyloxy)-2,5-diiodophenol

4-(N-(2-hydroxyethyl)-N-methylamino)-4′-nitrostilbene

1,4-diiodo-2,5-dimethoxybenzene

2,5-diiodo-1,4-hydroquinone