N-{9-(allyloxycarbonyl)-3-(tert-butoxycarbonyl)-15-[(9H-fluoren-9-yl)methyloxycarbonyl]-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl}carbamic acid phenylmethyl ester

Base Information

Chemical Name:N-{9-(allyloxycarbonyl)-3-(tert-butoxycarbonyl)-15-[(9H-fluoren-9-yl)methyloxycarbonyl]-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl}carbamic acid phenylmethyl ester
CAS No.:1352089-41-8
Molecular Formula:C₅₀H₆₆N₈O₁₂
Molecular Weight:971.12
Hs Code.:

N-{9-(allyloxycarbonyl)-3-(tert-butoxycarbonyl)-15-[(9H-fluoren-9-yl)methyloxycarbonyl]-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl}carbamic acid phenylmethyl ester

Synonyms:N-{9-(allyloxycarbonyl)-3-(tert-butoxycarbonyl)-15-[(9H-fluoren-9-yl)methyloxycarbonyl]-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl}carbamic acid phenylmethyl ester

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Chemical Property of N-{9-(allyloxycarbonyl)-3-(tert-butoxycarbonyl)-15-[(9H-fluoren-9-yl)methyloxycarbonyl]-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl}carbamic acid phenylmethyl ester

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Technology Process of N-{9-(allyloxycarbonyl)-3-(tert-butoxycarbonyl)-15-[(9H-fluoren-9-yl)methyloxycarbonyl]-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl}carbamic acid phenylmethyl ester

There total 11 articles about N-{9-(allyloxycarbonyl)-3-(tert-butoxycarbonyl)-15-[(9H-fluoren-9-yl)methyloxycarbonyl]-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl}carbamic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 1352089-40-7
N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycine

: 1352089-41-8
N-{9-(allyloxycarbonyl)-3-(tert-butoxycarbonyl)-15-[(9H-fluoren-9-yl)methyloxycarbonyl]-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl}carbamic acid phenylmethyl ester

Guidance literature:: N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycine; With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

4-(2-AMINOETHYL)MORPHOLINE; In dichloromethane; at -15 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1002/hlca.201100243

Reference yield:

: H-Aeg(Fmoc)-OMe*TFA

: 1352089-41-8
N-{9-(allyloxycarbonyl)-3-(tert-butoxycarbonyl)-15-[(9H-fluoren-9-yl)methyloxycarbonyl]-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl}carbamic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: triethylsilane / dichloromethane / 3 h / 0 - 20 °C

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: lithium hydroxide / tetrahydrofuran; water / 2 h / 0 - 20 °C

4.2: pH 3

5.1: 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

5.2: 4 h / -15 - 20 °C / Inert atmosphere

With triethylsilane; 1-hydroxy-pyrrolidine-2,5-dione; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100243

Reference yield:

: 1352089-37-2
methyl N-{2-[N-(2-tert-butoxycarbonylaminoethyl)-N-(prop-2-en-1-yloxycarbonyl)]glycylaminoethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate

: 1352089-41-8
N-{9-(allyloxycarbonyl)-3-(tert-butoxycarbonyl)-15-[(9H-fluoren-9-yl)methyloxycarbonyl]-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl}carbamic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylsilane / dichloromethane / 3 h / 0 - 20 °C

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: lithium hydroxide / tetrahydrofuran; water / 2 h / 0 - 20 °C

3.2: pH 3

4.1: 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

4.2: 4 h / -15 - 20 °C / Inert atmosphere

With triethylsilane; 1-hydroxy-pyrrolidine-2,5-dione; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100243