N-[9-(allyloxycarbonyl)-15-{2-[1,6-dihydro-6-oxo-2-(phenylmethoxycarbonylamino)-9H-purin-9-yl]acetyl}-3-(tert-butoxycarbonyl)-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl]carbamic acid phenylmethyl ester

Base Information

Chemical Name:N-[9-(allyloxycarbonyl)-15-{2-[1,6-dihydro-6-oxo-2-(phenylmethoxycarbonylamino)-9H-purin-9-yl]acetyl}-3-(tert-butoxycarbonyl)-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl]carbamic acid phenylmethyl ester
CAS No.:1352089-43-0
Molecular Formula:C₅₀H₆₇N₁₃O₁₄
Molecular Weight:1074.16
Hs Code.:

N-[9-(allyloxycarbonyl)-15-{2-[1,6-dihydro-6-oxo-2-(phenylmethoxycarbonylamino)-9H-purin-9-yl]acetyl}-3-(tert-butoxycarbonyl)-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl]carbamic acid phenylmethyl ester

Synonyms:N-[9-(allyloxycarbonyl)-15-{2-[1,6-dihydro-6-oxo-2-(phenylmethoxycarbonylamino)-9H-purin-9-yl]acetyl}-3-(tert-butoxycarbonyl)-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl]carbamic acid phenylmethyl ester

Suppliers and Price of N-[9-(allyloxycarbonyl)-15-{2-[1,6-dihydro-6-oxo-2-(phenylmethoxycarbonylamino)-9H-purin-9-yl]acetyl}-3-(tert-butoxycarbonyl)-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl]carbamic acid phenylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[9-(allyloxycarbonyl)-15-{2-[1,6-dihydro-6-oxo-2-(phenylmethoxycarbonylamino)-9H-purin-9-yl]acetyl}-3-(tert-butoxycarbonyl)-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl]carbamic acid phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[9-(allyloxycarbonyl)-15-{2-[1,6-dihydro-6-oxo-2-(phenylmethoxycarbonylamino)-9H-purin-9-yl]acetyl}-3-(tert-butoxycarbonyl)-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl]carbamic acid phenylmethyl ester

There total 12 articles about N-[9-(allyloxycarbonyl)-15-{2-[1,6-dihydro-6-oxo-2-(phenylmethoxycarbonylamino)-9H-purin-9-yl]acetyl}-3-(tert-butoxycarbonyl)-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl]carbamic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1352089-42-9
N-[9-(allyloxycarbonyl)-3-(tert-butoxycarbonyl)-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl]carbamic acid phenylmethyl ester

: 169287-69-8
2-[2-(benzyloxycarbonyl)amino-6-oxo-1,6-dihydro-9H-purin-9-yl]acetic acid

: 1352089-43-0
N-[9-(allyloxycarbonyl)-15-{2-[1,6-dihydro-6-oxo-2-(phenylmethoxycarbonylamino)-9H-purin-9-yl]acetyl}-3-(tert-butoxycarbonyl)-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl]carbamic acid phenylmethyl ester

Guidance literature:: With bromo-tris-dimethylamino-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/hlca.201100243

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 1352089-43-0
N-[9-(allyloxycarbonyl)-15-{2-[1,6-dihydro-6-oxo-2-(phenylmethoxycarbonylamino)-9H-purin-9-yl]acetyl}-3-(tert-butoxycarbonyl)-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl]carbamic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

1.2: 4 h / -15 - 20 °C / Inert atmosphere

2.1: diethylamine / dichloromethane / 1.5 h / 20 °C

3.1: bromo-tris-dimethylamino-phosphonium hexafluorophosphate; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With 1-hydroxy-pyrrolidine-2,5-dione; bromo-tris-dimethylamino-phosphonium hexafluorophosphate; diethylamine; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1002/hlca.201100243

Reference yield:

: 1352089-38-3
methyl N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate

: 1352089-43-0
N-[9-(allyloxycarbonyl)-15-{2-[1,6-dihydro-6-oxo-2-(phenylmethoxycarbonylamino)-9H-purin-9-yl]acetyl}-3-(tert-butoxycarbonyl)-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl]carbamic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 2 h / 0 - 20 °C

1.2: pH 3

2.1: 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

2.2: 4 h / -15 - 20 °C / Inert atmosphere

3.1: diethylamine / dichloromethane / 1.5 h / 20 °C

4.1: bromo-tris-dimethylamino-phosphonium hexafluorophosphate; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With 1-hydroxy-pyrrolidine-2,5-dione; bromo-tris-dimethylamino-phosphonium hexafluorophosphate; diethylamine; triethylamine; dicyclohexyl-carbodiimide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/hlca.201100243