N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycine

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Chemical Name:N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycine
CAS No.:1352089-40-7
Molecular Formula:C₄₄H₅₄N₆O₁₂
Molecular Weight:858.946
Hs Code.:

N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycine

Synonyms:N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycine

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Chemical Property of N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycine

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Technology Process of N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycine

There total 10 articles about N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1352089-38-3
methyl N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate

: 1352089-40-7
N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycine

Guidance literature:: methyl N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate; With lithium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 2h;

With potassium hydrogensulfate; In tetrahydrofuran; water; pH=3;
DOI:10.1002/hlca.201100243

Reference yield:

: H-Aeg(Fmoc)-OMe*TFA

: 1352089-40-7
N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycine

Guidance literature:: Multi-step reaction with 4 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: triethylsilane / dichloromethane / 3 h / 0 - 20 °C

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: lithium hydroxide / tetrahydrofuran; water / 2 h / 0 - 20 °C

4.2: pH 3

With triethylsilane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100243

Reference yield:

: H-Aeg(Alloc)-Aeg(Fmoc)-OMe*TFA

: 1352089-40-7
N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycine

Guidance literature:: Multi-step reaction with 2 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; water / 2 h / 0 - 20 °C

2.2: pH 3

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100243