(R)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Base Information

Chemical Name:(R)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester
CAS No.:870097-43-1
Molecular Formula:C₁₇H₂₁NO₅
Molecular Weight:319.357
Hs Code.:

Synonyms:(R)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

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Chemical Property of (R)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

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Technology Process of (R)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

There total 5 articles about (R)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 115-11-7,15220-85-6
isobutene

: 147226-04-8
(R)-1-((benzyloxy)carbonyl)-4-oxopyrrolidine-2-carboxylic acid

: 870097-43-1
(R)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Guidance literature:: With sulfuric acid; In dichloromethane; for 12h; Cooling with ice;
DOI:10.1016/j.tetlet.2016.09.032

Reference yield:

: 2584-71-6,30724-02-8
cis-hydroxy-D-proline

: 870097-43-1
(R)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: TMSCl; diisopropylethylamine / CH₂Cl₂ / 1.5 h / Heating

1.2: CH₂Cl₂ / 0 - 20 °C

2.1: Jones reagent / acetone / 3 h / 20 °C

3.1: H₂SO₄ / CH₂Cl₂ / 0 - 20 °C

With chloro-trimethyl-silane; jones reagent; sulfuric acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetone;
DOI:10.1021/jo051639u

Reference yield:

: 130930-25-5
(R,R)-4-hydroxy-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid

: 870097-43-1
(R)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Jones reagent / acetone / 3 h / 20 °C

2: H₂SO₄ / CH₂Cl₂ / 0 - 20 °C

With jones reagent; sulfuric acid; In dichloromethane; acetone;
DOI:10.1021/jo051639u