α-methyl 3-chlorophenylacetyl chloride

Base Information

• Chemical Name: α-methyl 3-chlorophenylacetyl chloride
• CAS No.: 51631-68-6
• Molecular Formula: C₉H₈Cl₂O
• Molecular Weight: 203.068
• Mol file: 51631-68-6.mol

Synonyms:α-methyl 3-chlorophenylacetyl chloride

Chemical Property of α-methyl 3-chlorophenylacetyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of α-methyl 3-chlorophenylacetyl chloride

There total 6 articles about α-methyl 3-chlorophenylacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-chlorophenyl) propanoic acid (14161-84-3) → α-methyl 3-chlorophenylacetyl chloride (51631-68-6)

Guidance literature:

With thionyl chloride; at 60 ℃; for 3h;

DOI:10.1021/jm00037a022

Reference yield:

3-chlorophenylacetic acid (1878-65-5) → α-methyl 3-chlorophenylacetyl chloride (51631-68-6)

Guidance literature:

Multi-step reaction with 5 steps

1: SOCl₂ / 1 h / 60 °C

2: CH₂Cl₂ / 1 h / 40 °C

3: 1.) NaNH₂ / 1.) toluene, RT, 10 min, 2.) toluene, RT, 40 min

4: H₂O, ethan. KOH / ethanol / 24 h / Heating

5: SOCl₂ / 3 h / 60 °C

With potassium hydroxide; thionyl chloride; water; sodium amide; In ethanol; dichloromethane;

DOI:10.1021/jm00037a022

Reference yield:

(3-Chloro-phenyl)-acetic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester → α-methyl 3-chlorophenylacetyl chloride (51631-68-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaNH₂ / 1.) toluene, RT, 10 min, 2.) toluene, RT, 40 min

2: H₂O, ethan. KOH / ethanol / 24 h / Heating

3: SOCl₂ / 3 h / 60 °C

With potassium hydroxide; thionyl chloride; water; sodium amide; In ethanol;

DOI:10.1021/jm00037a022

upstream raw materials:

2-(3-chlorophenyl) propanoic acid

3-chlorophenylacetic acid

3-chloro-benzeneacetyl chloride

Methyl-2-(3-chlorophenyl) propanoate