2-(3-CHLORO-PHENYL)-PROPIONIC ACID METHYL ESTER

Base Information

• Chemical Name: 2-(3-CHLORO-PHENYL)-PROPIONIC ACID METHYL ESTER
• CAS No.: 103040-42-2
• Molecular Formula: C10H11 Cl O2
• Molecular Weight: 198.649
• Hs Code.: 2916399090
• Mol file: 103040-42-2.mol

Synonyms:Hydratropicacid, m-chloro-, methyl ester (6CI)

Chemical Property of 2-(3-CHLORO-PHENYL)-PROPIONIC ACID METHYL ESTER

Chemical Property:

• PSA: 26.30000
• LogP: 2.44560

Purity/Quality:

97% ^*data from raw suppliers

2-(3-Chloro-phenyl)-propionicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-CHLORO-PHENYL)-PROPIONIC ACID METHYL ESTER

There total 21 articles about 2-(3-CHLORO-PHENYL)-PROPIONIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3'-chloro-propiophenone (34841-35-5) + trimethyl orthoformate (149-73-5) → Methyl-2-(3-chlorophenyl) propanoate (103040-42-2)

Guidance literature:

With perchloric acid; thallium(III) toluene-p-sulfonate; at 20 ℃; for 4h;

DOI:10.5012/jkcs.2017.61.3.125

Reference yield: 81.0%

methanol (67-56-1) + 3'-chloro-propiophenone (34841-35-5) → Methyl-2-(3-chlorophenyl) propanoate (103040-42-2)

Guidance literature:

With sulfuric acid; trimethyl orthoformate; for 0.333333h; Heating;

DOI:10.1016/j.tetlet.2007.02.129

Reference yield: 71.0%

trimethylsilylazide (4648-54-8) + 3-Chlorostyrene (2039-85-2,26100-04-9) + tetra(n-butyl)ammonium formate (35733-58-5) → Methyl-2-(3-chlorophenyl) propanoate (103040-42-2)

Guidance literature:

3-Chlorostyrene; tetra(n-butyl)ammonium formate; With C₂₂H₃₁F₃GeO₃P₂PdS; In N,N-dimethyl-formamide; at 100 ℃; for 12h; Inert atmosphere; Green chemistry;

trimethylsilylazide; In methanol; diethyl ether; at 0 ℃; for 0.5h; Reagent/catalyst; Solvent; Temperature; Concentration; regioselective reaction; Catalytic behavior; Inert atmosphere; Green chemistry;

DOI:10.1039/c7cc01377a

upstream raw materials:

methanol

(S)-(+)-2-(3'-chlorophenyl)propanoic acid

rac-2-(3-chlorophenyl)propanenitrile

methyl 3-chlorophenylacetate

Downstream raw materials:

2-(3-chlorophenyl) propanoic acid

2-(3-chlorophenyl) propan-1-ol

2-(3-chlorophenyl) propyl methanesulfonate

2-(3-chlorophenyl) propyl phthalimide