2-HYDROXYMETHYL-6-METHOXY-1,4-BENZOQUINONE

Base Information

• Chemical Name: 2-HYDROXYMETHYL-6-METHOXY-1,4-BENZOQUINONE
• CAS No.: 50827-57-1
• Molecular Formula: C8H8 O4
• Molecular Weight: 168.15
• Mol file: 50827-57-1.mol

Synonyms:2-(Hydroxymethyl)-6-methoxy-1,4-benzoquinone;2-Hydroxymethyl-6-methoxybenzoquinone; NSC 271291

Chemical Property of 2-HYDROXYMETHYL-6-METHOXY-1,4-BENZOQUINONE

Chemical Property:

• Vapor Pressure: 4.37E-06mmHg at 25°C
• Melting Point: 155-157 °C(lit.)
• Boiling Point: 343.9°Cat760mmHg
• Flash Point: 145°C
• PSA: 63.60000
• Density: 1.32g/cm³
• LogP: -0.41280

Purity/Quality:

99.90% ^*data from raw suppliers

2-HYDROXYMETHYL-6-METHOXY-1,4-BENZOQUINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-HYDROXYMETHYL-6-METHOXY-1,4-BENZOQUINONE

There total 4 articles about 2-HYDROXYMETHYL-6-METHOXY-1,4-BENZOQUINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3,5-dimethoxybenzyl alcohol (705-76-0) → 2-methoxy-6-hydroxymethyl-1,4-benzoquinone (50827-57-1)

Guidance literature:

With C₃₃H₃₃N₅O₈Ru; dihydrogen peroxide; In ethyl acetate; at 20 ℃; for 15h; chemoselective reaction; Schlenk technique; Green chemistry;

DOI:10.1039/c6ob00969g

Reference yield: 86.0%

2-hydroxy-3-methoxybenzyl alcohol (4383-05-5) → 2-methoxy-6-hydroxymethyl-1,4-benzoquinone (50827-57-1)

Guidance literature:

With salcomine; oxygen; In N,N-dimethyl-formamide; for 48h;

DOI:10.1021/jo00221a019

Reference yield: 65.0%

2-hydroxy-3-methoxy-5-bromobenzyl alcohol (35090-64-3) → 2-methoxy-6-hydroxymethyl-1,4-benzoquinone (50827-57-1)

Guidance literature:

With potassium nitrososulfonate; In water; acetone; for 0.25h; Mechanism; Na₂HPO₄-NaH₂PO₄ buffer pH=5.8;

DOI:10.1016/S0040-4020(01)81645-8

upstream raw materials:

2-hydroxy-3-methoxybenzyl alcohol

2-methoxy-4,6-bishydroxymethyl phenol

2-hydroxy-3-methoxy-5-bromobenzyl alcohol

3,5-dimethoxybenzyl alcohol

Downstream raw materials:

Methyl-carbamic acid 5-methoxy-3,6-dioxo-cyclohexa-1,4-dienylmethyl ester

Refernces

• 1、 Deya, Pedro M.,Dopico, Mercedes,Raso, Angel Garcia,Morey, Jeronimo,Saa, Jose M.. "ON THE REGIOSELECTIVITY OF THE FREMY'S SALT OXIDATION OF PHENOLS". . p. 3523 - 3532. Retrieved 2007/10/02.