35090-64-3

Usage

Uses

Used in Organic Synthesis:
4-BROMO-2-(HYDROXYMETHYL)-6-METHOXYBENZENOL is used as a key intermediate in organic synthesis for the production of various pharmaceuticals, agrochemicals, and fine chemicals. Its unique structure allows for the creation of a wide range of derivatives with diverse applications.
Used in Pharmaceutical Research:
In Pharmaceutical Research, 4-BROMO-2-(HYDROXYMETHYL)-6-METHOXYBENZENOL is used as a starting material for the development of new medications. Its antioxidant and anti-inflammatory properties make it a promising candidate for the treatment of various diseases and conditions.
Used in Antioxidant Applications:
4-BROMO-2-(HYDROXYMETHYL)-6-METHOXYBENZENOL is used as an antioxidant in various industries, including food, cosmetics, and pharmaceuticals, to prevent oxidation and extend the shelf life of products.
Used in Anti-Inflammatory Applications:
In Anti-Inflammatory Applications, 4-BROMO-2-(HYDROXYMETHYL)-6-METHOXYBENZENOL is used for its potential to reduce inflammation and alleviate symptoms associated with inflammatory conditions.
Used in Drug Development:
In Drug Development, 4-BROMO-2-(HYDROXYMETHYL)-6-METHOXYBENZENOL is used as a lead compound for the discovery and optimization of new therapeutic agents with antioxidant and anti-inflammatory effects.
Used in Agrochemicals:
In the Agrochemical Industry, 4-BROMO-2-(HYDROXYMETHYL)-6-METHOXYBENZENOL is used as a building block for the synthesis of various agrochemicals, such as pesticides and herbicides, to improve crop protection and yield.
Overall, 4-BROMO-2-(HYDROXYMETHYL)-6-METHOXYBENZENOL's diverse applications across different industries highlight its importance as a versatile chemical compound with significant potential in research and development.

InChI:InChI=1/C8H9BrO3/c1-12-7-3-6(9)2-5(4-10)8(7)11/h2-3,10-11H,4H2,1H3

Upstream product

• 5034-74-2 5-bromo-3-methoxysalicylaldehyde 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 

Downstream Products

• 144735-57-9 2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxypropyl)-7-methoxybenzofurane 
• 144735-56-8 5-((2-methoxycarbonyl)ethyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran 
• 17375-66-5 5-(3''-hydroxypropyl)-7-methoxy-2-(3',4'-dimethoxyphenyl)benzofuran 
• 530-22-3 egonol 
• 144735-55-7 5-(2-(methoxycarbonyl)trans-ethenyl)-7-methoxy-2-(3'-methoxy-4'-(benzyloxy)phenyl)benzofuran 
• 213970-70-8 5-(2-(ethoxycarbonyl)-E-ethenyl)-7-methoxy-2-(3-methoxy-4-benzyloxyphenyl)benzofuran 
• 215585-89-0 5-(2-(ethoxycarbonyl)-E-ethenyl)-7-methoxy-2-phenylbenzofuran 
• 164414-62-4 5-bromo-7-methoxybenzofuran 
• 515814-05-8 2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran 
• 1218818-74-6 5-bromo-2-(3,4-dimethoxyphenyl)-7-methoxybenzofuran 

Relevant academic research and scientific papers

Novel titanium(IV) complexes stabilized by 2-hydroxybenzyl alcohol derivatives as catalysts for UHMWPE production

A series of titanium (IV) complexes (2, 5-7) stabilized by a substituted 2-hydroxybenzyl alcohols (1, 4) – were synthesized. Structures of complexes 6-7 were determined by X-ray diffraction. Titanium atom in the tetrameric complex 6 has an octahedral envi

An alternate method for the synthesis of 2-aryl/alkyl-5-bromo-7-methoxy benzofurans; application to the synthesis of Egonol, Homoegonol, and analogs via Heck reaction

We herein report the general, versatile, and convenient method for the synthesis of 2-arly/alkyl-5-bromo-7-methoxy benzofurans from easily available o-Vanillin in five steps. These benzofurans was successfully converted into biological active natural products Egonol, Homoegonol, and analogous on applying Heck reaction using ethyl/methyl acrylate in the presence of palladium catalyst.

Approach to Merosesquiterpenes via Lewis Acid Catalyzed Nazarov-Type Cyclization: Total Synthesis of Akaol A

A Lewis acid catalyzed Nazarov-type cyclization of arylvinylcarbinol has been developed for the asymmetric synthesis of carbotetracyclic core of merosesquiterpenes. The reaction works only in the presence of 2 mol % of Sn(OTf)2 and Bi(OTf)3 in dichloroethane under elevated temperature. The methodology offers the synthesis of a variety of enantioenriched arylvinylcarbinols from commercially available (3aR)-sclareolide 9 in six steps with an eventual concise total synthesis of marine sesquiterpene quinol, akaol A (1a).

2,3-DIHYDRO-IMINOISOINDOLE DERIVATIVES

A compound represented by the following general formula (1), or a salt thereof has serine protease inhibiting activity, and particularly excellent inhibiting activity against clotting factor VIIa. This compound or a salt thereof is useful as therapeutic and/or prophylactic agents for diseases associated with thrombus formation. [wherein R1 represents hydrogen, R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc.]

Novel 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran derivatives as selective α2C-adrenergic receptor antagonists

The synthesis of a series of 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methyl-2-arylbenzofuran and 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran-2-carboxamide derivatives as novel α2C-adrenergic receptor antagonists are described. Their affinity at three different human α2-adrenergic receptors is reported, and some of these compounds exhibited high affinity for the α2C-adrenergic receptor with high subtype selectivity. Among them, compound 10e has been found to show the anti-l-dopa-induced dyskinetic activity in marmosets. The structure-activity relationship of these compounds is also discussed.

Metalloantimalarials: Synthesis and characterization of a novel agent possessing activity against Plasmodium falciparum

The synthesis, characterization, and antimalarial potency of an amine-phenol complex of gallium(III), [{1,12-bis(2-hydroxy-3-methoxy-5- (quinolin-3-yl)-benzyl)-1,5,8,12-tetraazadodecane}-gallium(III)]+, [Ga-3-M-5-Quadd]+ (7) is descr

ON THE REGIOSELECTIVITY OF THE FREMY'S SALT OXIDATION OF PHENOLS

A detailed study of the regioselectivity of the Fremy's salt oxidation of phenols, including a series of MNDO calculations of the intermediate phenoxy radicals, has been carried out.The analysis of these results has led us to establish a new rule for the para vs. ortho regioselectivity, namely: "C-4 unsubstituted phenols, as well as phenols substituted at C-4 with easy-to-displace groups, undergo oxidation (or oxidative degradation) by the action of Fremy's salt, thus eventually providing the corresponding p-quinones".A similar rule for the ortho vs. ortho' regioselectivity could not be so precisely formulated since now steric effects play a significant major role.