(2S,5S)-9-bromo-6,6-dimethoxy-2-phenyl-1,4-dioxaspiro[4.5]deca-7,9-diene

Base Information

Chemical Name:(2S,5S)-9-bromo-6,6-dimethoxy-2-phenyl-1,4-dioxaspiro[4.5]deca-7,9-diene
CAS No.:817622-46-1
Molecular Formula:C₁₆H₁₇BrO₄
Molecular Weight:353.213
Hs Code.:

Synonyms:(2S,5S)-9-bromo-6,6-dimethoxy-2-phenyl-1,4-dioxaspiro[4.5]deca-7,9-diene

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Chemical Property of (2S,5S)-9-bromo-6,6-dimethoxy-2-phenyl-1,4-dioxaspiro[4.5]deca-7,9-diene

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Technology Process of (2S,5S)-9-bromo-6,6-dimethoxy-2-phenyl-1,4-dioxaspiro[4.5]deca-7,9-diene

There total 3 articles about (2S,5S)-9-bromo-6,6-dimethoxy-2-phenyl-1,4-dioxaspiro[4.5]deca-7,9-diene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 67-56-1
methanol

: 817622-22-3
(S)-2-(5-bromo-2-methoxyphenoxy)-1-phenylethanol

: 817622-46-1
(2S,5S)-9-bromo-6,6-dimethoxy-2-phenyl-1,4-dioxaspiro[4.5]deca-7,9-diene

Guidance literature:: With potassium hydroxide; at 0 ℃; Electrolysis;
DOI:10.1021/ol048030k

Reference yield:

: 37942-01-1
5-bromo-2-methoxyphenol

: 817622-46-1
(2S,5S)-9-bromo-6,6-dimethoxy-2-phenyl-1,4-dioxaspiro[4.5]deca-7,9-diene

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / potassium carbonate; potassium iodide / toluene / 120 h / 150 °C

2: 14 percent / KOH / 0 °C / Electrolysis

With potassium hydroxide; potassium carbonate; potassium iodide; In toluene; 1: Williamson etherification;
DOI:10.1021/ol048030k

Reference yield:

: 25016-01-7
5-bromo-2-methoxybenzaldehyde

: 817622-46-1
(2S,5S)-9-bromo-6,6-dimethoxy-2-phenyl-1,4-dioxaspiro[4.5]deca-7,9-diene

Guidance literature:: Multi-step reaction with 3 steps

1.1: peracetic acid; acetic acid / ethyl acetate / cooling

1.2: 65 percent / KOH / methanol / 0.5 h / 0 °C

2.1: 48 percent / potassium carbonate; potassium iodide / toluene / 120 h / 150 °C

3.1: 14 percent / KOH / 0 °C / Electrolysis

With peracetic acid; potassium hydroxide; potassium carbonate; acetic acid; potassium iodide; In ethyl acetate; toluene; 2.1: Williamson etherification;
DOI:10.1021/ol048030k