(Z)-5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)-1-((5-(2-nitrophenyl)furan-2-yl)methyl)pyrimidine-2,4(1H,3H)dione

Base Information

Chemical Name:(Z)-5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)-1-((5-(2-nitrophenyl)furan-2-yl)methyl)pyrimidine-2,4(1H,3H)dione
CAS No.:1338233-18-3
Molecular Formula:C₁₉H₁₃N₅O₆S
Molecular Weight:439.408
Hs Code.:

Synonyms:(Z)-5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)-1-((5-(2-nitrophenyl)furan-2-yl)methyl)pyrimidine-2,4(1H,3H)dione

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Chemical Property of (Z)-5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)-1-((5-(2-nitrophenyl)furan-2-yl)methyl)pyrimidine-2,4(1H,3H)dione

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Technology Process of (Z)-5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)-1-((5-(2-nitrophenyl)furan-2-yl)methyl)pyrimidine-2,4(1H,3H)dione

There total 6 articles about (Z)-5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)-1-((5-(2-nitrophenyl)furan-2-yl)methyl)pyrimidine-2,4(1H,3H)dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1338233-12-7
1-((5-(2-nitrophenyl)furan-2-yl)methyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde

: 556-90-1
pseudothiohydantoin

: 1338233-18-3
(Z)-5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)-1-((5-(2-nitrophenyl)furan-2-yl)methyl)pyrimidine-2,4(1H,3H)dione

Guidance literature:: With sodium acetate; In acetic acid; at 135 ℃; for 12h;
DOI:10.1016/j.bmcl.2011.07.107

Reference yield:

: 1899-24-7
5-bromo-2-furancarboxaldehyde

: 1338233-18-3
(Z)-5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)-1-((5-(2-nitrophenyl)furan-2-yl)methyl)pyrimidine-2,4(1H,3H)dione

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene / 3 h / 120 °C

2: sodium tetrahydroborate / ethanol / 0 - 25 °C

3: phosphorus tribromide / dichloromethane / 0 - 25 °C

4: potassium carbonate / N,N-dimethyl-formamide / 8 h / 50 °C

5: sodium acetate / acetic acid / 12 h / 135 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium acetate; phosphorus tribromide; potassium carbonate; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene; 5: Knoevenagel condensation;
DOI:10.1016/j.bmcl.2011.07.107

Reference yield:

: 20000-96-8
5-(2-nitrophenyl)-2-furaldehyde

: 1338233-18-3
(Z)-5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)-1-((5-(2-nitrophenyl)furan-2-yl)methyl)pyrimidine-2,4(1H,3H)dione

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / ethanol / 0 - 25 °C

2: phosphorus tribromide / dichloromethane / 0 - 25 °C

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 50 °C

4: sodium acetate / acetic acid / 12 h / 135 °C

With sodium tetrahydroborate; sodium acetate; phosphorus tribromide; potassium carbonate; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; 4: Knoevenagel condensation;
DOI:10.1016/j.bmcl.2011.07.107