556-90-1

Basic information

• Product Name: Pseudothiohydantoin
• Synonyms: BUTTPARK 148\07-35;AURORA 16732;2-IMINO-THIAZOLIDIN-4-ONE;2-AMINO-1,3-THIAZOLIN-4-ONE;2-AMINO-4,5-DIHYDRO-1,3-THIAZOL-4-ONE;2-AMINO-4,5-DIHYDRO-1,3-THIAZOL-4-ONE HYDROCHLORIDE;2-AMINOTHIAZOLINONE HCL;2-AMINOTHIAZOLE-4-ONE HYDROCHLORIDE
• CAS NO: 556-90-1
• Molecular Formula: C₃H₄N₂OS
• Molecular Weight: 116.14
• EINECS: 209-145-6
• Product Categories: Amines;Thiazoles, Isothiazoles &Benzothiazoles;Thiazoles, Isothiazoles & Benzothiazoles;Building Blocks;Heterocyclic Building Blocks;Thiazolines/Thiazolidines;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 556-90-1.mol
• Article Data: 24

Chemical Properties

• Melting Point: 249 °C (dec.)(lit.)
• Boiling Point: 253.5 °C at 760 mmHg
• Flash Point: 107.1 °C
• Appearance: /solid
• Density: 1.637 g/cm3
• Vapor Pressure: 0.0182mmHg at 25°C
• Refractive Index: 1.6550 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 0.54±0.20(Predicted)
• CAS DataBase Reference: Pseudothiohydantoin(CAS DataBase Reference)
• NIST Chemistry Reference: Pseudothiohydantoin(556-90-1)
• EPA Substance Registry System: Pseudothiohydantoin(556-90-1)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: XJ6276000
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 556-90-1(Hazardous Substances Data)

Usage

Chemical Properties

white to yellowish fine needles or powder

Uses

2-Amino-4,5-dihydro-1,3-thiazol-4-one, HCl

InChI:InChI=1/C3H4N2OS/c4-3-5-2(6)1-7-3/h1H2,(H2,4,5,6)

Upstream product

• 5349-28-0 thiocyanato-acetic acid ethyl ester 
• 4791-22-4 1-(chloroacetyl)-3-methylurea 
• 333-20-0 potassium thioacyanate 
• 420-04-2 CYANAMID 
• 68-11-1 mercaptoacetic acid 
• 17356-08-0 thiourea 
• 79-11-8 chloroacetic acid 
• 598-21-0 2-Bromoacetyl bromide 
• 16634-82-5 N-(p-tolyl)-2-chloroacetamide 
• 79-07-2 Chloroacetamide 
• 4791-23-5 N-chloroacetyl-N'-phenylurea 
• 2365-48-2 Methyl thioglycolate 
• 7647-01-0 hydrogenchloride 
• 5425-41-2 2-amino-4-oxo-4,5-dihydro-thiazole-5-carboxylic acid ethyl ester 

Downstream Products

• 39764-11-9 2-(4-chloro-2-methyl-phenoxy)-N-(4-oxo-4,5-dihydro-thiazol-2-ylcarbamoyl)-acetamide 
• 39764-12-0 1-benzoyl-3-(4-oxo-4,5-dihydro-thiazol-2-yl)-urea 
• 88696-51-9 2-diphenylaminomethyliminothiazolidin-4-one 
• 88696-72-4 3-tert-Butyl-6-oxo-7,7-bis(hydroxymethyl)-2,3,4,5,6,7-hexahydrothiazolo<3,2-a>-1,3,5-triazine 
• 78153-30-7 3-phenyl-6-oxo-2,3,4,5,6,7-hexahydrothiazolo<3,2-a>-1,3,5-triazine 
• 78153-33-0 3-(3-Chloro-phenyl)-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-6-one 
• 78153-31-8 3-m-Tolyl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-6-one 
• 78659-62-8 3-(3-Nitro-phenyl)-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-6-one 
• 88696-73-5 3-Benzyl-6-oxo-7,7-bis(hydroxymethyl)-2,3,4,5,6,7-hexahydrothiazolo<3,2-a>-1,3,5-triazine 
• 78153-34-1 3-(3-Bromo-phenyl)-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-6-one 
• 68-11-1 mercaptoacetic acid 
• 127099-85-8 N-Cyanoguanidine 
• 144-62-7 oxalic acid 
• 57-13-6 urea 

Relevant articles and documents

ADAMANTANE DERIVATIVES IV. SYNTHESIS AND ANTIVIRAL ACTIVITY OF SOME AMIDES CONTAINING THE ADAMANTYL GROUP

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Synthesis and Anticancer Activity of (E)-5-[(1-Aryl-1H-1,2,3-triazol-4-yl)methylene]thiazolidine-2,4-diones

Abstract: A novel series of 1,2,3-triazolylthiazolidinedione analogs have been synthesized by the condensation of the corresponding 1-aryl-1H-1,2,3-triazole-4-carbaldehydes with thiazolidine-2,4-dione in the presence of KOH. The title compounds were evaluated for their in vitro anticancer activity using MTT assay against four cancer cell lines: A549 (lung), HT-29 (colon), MCF-7 (breast), and A375 (melanoma). Most compounds displayed good anticancer activity, but hydroxy- and nitro-substituted derivatives showed higher activity than the others.

A 5 - (1 H - indole - 3 - methylene) - 1, 3 - thiazolidine - 4 - ketone derivative and its synthetic method and application

The invention relates to 5-(1H-indolyl-3-methylene)-1,3-thiazolidinyl-4-one derivatives, and a synthesis method and application thereof. By using ethanol and/or water as a solvent, substituted 2-substituted-imino-1,3-thiazolidinyl-4-one and 1H-indolyl-3-formaldehyde are subjected to reflux reaction under the catalytic condition of piperidine through intermolecular dehydration condensation reaction to form methylene linking group, thereby obtaining the 5-(1H-indolyl-3-methylene)-1,3-thiazolidinyl-4-one derivatives. The intermediate 2-substituted-iminothiazolidinyl-4-one is prepared by carrying out cyclization reaction on various monosubstituted ethyl thiocarbamide chloroacetates or chloroacetic acids in a low-boiling solvent under reflux conditions, and the intermediate 2-substituted-imino-3-substituted-1,3-thiazolidinyl-4-one is prepared by carrying out a green environment-friendly synthesis technique on various disubstituted symmetric thiocarbamides and chloroacetic acids. The bioactivity preliminary screening experiment result of all the target compounds on the enzyme molecular level indicates that the target products have certain inhibition activity on PTP1B and CDC25B to different degrees.