Technology Process of (S)-4-benzyl-6-methoxy-1-phenyl-3,4-dihydroisoquinoline
There total 9 articles about (S)-4-benzyl-6-methoxy-1-phenyl-3,4-dihydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
phosphorus pentachloride;
In
acetonitrile;
at 0 - 20 ℃;
for 14h;
DOI:10.1021/jo0258251
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: (-)-sparteine; sec-BuLi / various solvent(s); tetrahydrofuran; cyclohexane / 1 h / -78 °C
1.2: various solvent(s); tetrahydrofuran; cyclohexane / 1 h / -78 °C
2.1: 1.5M n-BuLi / tetrahydrofuran / 12 h / -78 - 20 °C
3.1: KOH / dioxane; H2O / 18 h / Heating
4.1: acetyl chloride / ethyl acetate; ethanol / 19 h / 0 - 20 °C
5.1: triethylamine / CH2Cl2 / 24 h / 0 - 20 °C
6.1: phosphorus pentachloride / acetonitrile / 14 h / 0 - 20 °C
With
potassium hydroxide; n-butyllithium; phosphorus pentachloride; sec.-butyllithium; triethylamine; acetyl chloride; (-)-sparteine;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; cyclohexane; water; ethyl acetate; acetonitrile;
DOI:10.1021/jo0258251
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triethylamine / CH2Cl2 / 24 h / 0 - 20 °C
2: phosphorus pentachloride / acetonitrile / 14 h / 0 - 20 °C
With
phosphorus pentachloride; triethylamine;
In
dichloromethane; acetonitrile;
DOI:10.1021/jo0258251
