4-(4-TRIFLUOROMETHYLPHENYL)TETRAHYDRO-2H-PYRAN-4-CARBOXYLIC ACID

Base Information

• Chemical Name: 4-(4-TRIFLUOROMETHYLPHENYL)TETRAHYDRO-2H-PYRAN-4-CARBOXYLIC ACID
• CAS No.: 473706-07-9
• Molecular Formula: C₁₃H₁₃F₃O₃
• Molecular Weight: 274.24
• Mol file: 473706-07-9.mol

Synonyms:4-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carboxylic acid

Chemical Property of 4-(4-TRIFLUOROMETHYLPHENYL)TETRAHYDRO-2H-PYRAN-4-CARBOXYLIC ACID

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

4-[4-(Trifluoromethyl)phenyl]tetrahydro-2H-pyran-4-carboxylic acid AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-TRIFLUOROMETHYLPHENYL)TETRAHYDRO-2H-PYRAN-4-CARBOXYLIC ACID

There total 2 articles about 4-(4-TRIFLUOROMETHYLPHENYL)TETRAHYDRO-2H-PYRAN-4-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1'-oxybis(2-bromo-ethane) (5414-19-7) + (4-trifluoromethylphenyl)acetic acid ethyl ester (721-63-1) → 4-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carboxylic acid (473706-07-9)

Guidance literature:

(4-trifluoromethylphenyl)acetic acid ethyl ester; With sodium hydride; In 1-methyl-pyrrolidin-2-one; at 0 ℃; for 0.166667h;

1,1'-oxybis(2-bromo-ethane); In 1-methyl-pyrrolidin-2-one; at 0 - 23 ℃; for 20.25h;

With hydrogenchloride; water;

Reference yield:

4-Trifluoromethylphenylacetic acid (32857-62-8) → 4-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carboxylic acid (473706-07-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid / 48 h / Heating / reflux

2.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 0.17 h / 0 °C

2.2: 20.25 h / 0 - 23 °C

With sulfuric acid; sodium hydride; In 1-methyl-pyrrolidin-2-one;

Reference yield:

4-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carboxylic acid (473706-07-9) → C13H12ClF3O2

Guidance literature:

With thionyl chloride; for 2h; Heating / reflux;

upstream raw materials:

1,1'-oxybis(2-bromo-ethane)

(4-trifluoromethylphenyl)acetic acid ethyl ester

4-Trifluoromethylphenylacetic acid

Downstream raw materials:

diethyl 2-(4-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate