diethyl 2-(4-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Base Information

Chemical Name:diethyl 2-(4-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate
CAS No.:1035260-96-8
Molecular Formula:C₂₀H₂₃F₃O₆
Molecular Weight:416.394
Hs Code.:

Synonyms:diethyl 2-(4-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

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Chemical Property of diethyl 2-(4-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

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Technology Process of diethyl 2-(4-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

There total 4 articles about diethyl 2-(4-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₂ClF₃O₂

: 105-53-3
diethyl malonate

: 1035260-96-8
diethyl 2-(4-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Guidance literature:: diethyl malonate; With triethylamine; magnesium chloride; In acetonitrile; at 0 - 23 ℃; for 2.5h;

C₁₃H₁₂ClF₃O₂; In acetonitrile; at 23 - 50 ℃; for 15h;

Reference yield:

: 473706-07-9
4-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carboxylic acid

: 1035260-96-8
diethyl 2-(4-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 2 h / Heating / reflux

2.1: triethylamine; magnesium chloride / acetonitrile / 2.5 h / 0 - 23 °C

2.2: 15 h / 23 - 50 °C

With thionyl chloride; triethylamine; magnesium chloride; In acetonitrile;

Reference yield:

: 721-63-1
(4-trifluoromethylphenyl)acetic acid ethyl ester

: 1035260-96-8
diethyl 2-(4-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 0.17 h / 0 °C

1.2: 20.25 h / 0 - 23 °C

2.1: thionyl chloride / 2 h / Heating / reflux

3.1: triethylamine; magnesium chloride / acetonitrile / 2.5 h / 0 - 23 °C

3.2: 15 h / 23 - 50 °C

With thionyl chloride; sodium hydride; triethylamine; magnesium chloride; In 1-methyl-pyrrolidin-2-one; acetonitrile;