methyl-2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoate

Base Information

Chemical Name:methyl-2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoate
CAS No.:304682-71-1
Molecular Formula:C₁₆H₂₂N₂O₅
Molecular Weight:322.361
Hs Code.:

Synonyms:methyl-2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl-2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoate

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Technology Process of methyl-2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoate

There total 1 articles about methyl-2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 266338-68-5
rac-2-methyl-2-[(3-hydroxy-2-phenylpropanoyl)amino]propanoic acid

: 304682-71-1
methyl-2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoate

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In acetonitrile; at 20 ℃; for 22h;
DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G

Reference yield: 54.0%

: 304682-71-1
methyl-2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoate

: 304682-72-2
2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 20h;
DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G

Reference yield:

: 304682-71-1
methyl-2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoate

: 304682-76-6
2-[(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-1-oxoethyl]amino}-2-methyl-1-oxopropyl)amino]ethanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 54 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 20 h / 20 °C

2: 65 percent / acetonitrile / 17 h / 20 °C

3: 93 percent / 3N HCl / tetrahydrofuran / 45 h / 20 °C / and 40 deg C, 6 h

4: 39 percent / O-(1H-benzotriazol-1-yl)-N,N,N',N'-(Me₄)uronium⁽¹⁺⁾ BF₄^(1-); 1-HO-1H-benzotriazole (HOBt); Et₃N / acetonitrile / 13 h / 20 °C

5: 95 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 19 h / 20 °C

With hydrogenchloride; lithium hydroxide; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; methanol; water; acetonitrile; 1: Hydrolysis / 2: Addition / 3: Hydrolysis / 4: Condensation / 5: Hydrolysis;
DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G