2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoic acid

Base Information

Chemical Name:2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoic acid
CAS No.:304682-72-2
Molecular Formula:C₁₅H₂₀N₂O₅
Molecular Weight:308.334
Hs Code.:

Synonyms:2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoic acid

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Chemical Property of 2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoic acid

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Technology Process of 2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoic acid

There total 2 articles about 2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 304682-71-1
methyl-2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoate

: 304682-72-2
2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 20h;
DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G

Reference yield:

: 266338-68-5
rac-2-methyl-2-[(3-hydroxy-2-phenylpropanoyl)amino]propanoic acid

: 304682-72-2
2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / O-(1H-benzotriazol-1-yl)-N,N,N',N'-(Me₄)uronium⁽¹⁺⁾ BF₄^(1-); 1-HO-1H-benzotriazole (HOBt); Et₃N / acetonitrile / 22 h / 20 °C

2: 54 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 20 h / 20 °C

With lithium hydroxide; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; methanol; water; acetonitrile; 1: Condensation / 2: Hydrolysis;
DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G

Reference yield:

: 304682-72-2
2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoic acid

: 5,5,12,12,18,18-hexamethyl-9-phenyl-7-oxa-1,4,11,14,17-pentaazabicyclo[14.3.0.]nonadec-16-ene-3,6,10,13,19-pentone

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent / acetonitrile / 17 h / 20 °C

2: 93 percent / 3N HCl / tetrahydrofuran / 45 h / 20 °C / and 40 deg C, 6 h

3: 39 percent / O-(1H-benzotriazol-1-yl)-N,N,N',N'-(Me₄)uronium⁽¹⁺⁾ BF₄^(1-); 1-HO-1H-benzotriazole (HOBt); Et₃N / acetonitrile / 13 h / 20 °C

4: 95 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 19 h / 20 °C

5: 41 percent / acetonitrile / 44 h / 20 °C

6: 22 percent / HCl (gas) / toluene / 0.33 h / 100 °C

With hydrogenchloride; lithium hydroxide; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; methanol; water; toluene; acetonitrile; 1: Addition / 2: Hydrolysis / 3: Condensation / 4: Hydrolysis / 5: Addition / 6: Cyclization;
DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G