2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-1-oxoethyl]amino}-2-methylpropanoic acid

Base Information

Chemical Name:2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-1-oxoethyl]amino}-2-methylpropanoic acid
CAS No.:304682-74-4
Molecular Formula:C₁₉H₂₇N₃O₆
Molecular Weight:393.44
Hs Code.:

Synonyms:2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-1-oxoethyl]amino}-2-methylpropanoic acid

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Chemical Property of 2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-1-oxoethyl]amino}-2-methylpropanoic acid

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Technology Process of 2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-1-oxoethyl]amino}-2-methylpropanoic acid

There total 4 articles about 2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-1-oxoethyl]amino}-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 304682-73-3
2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-1-oxoethyl]amino}-2,N,N-trimethylpropanamide

: 304682-74-4
2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-1-oxoethyl]amino}-2-methylpropanoic acid

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 45h; and 40 deg C, 6 h;
DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G

Reference yield:

: 266338-68-5
rac-2-methyl-2-[(3-hydroxy-2-phenylpropanoyl)amino]propanoic acid

: 304682-74-4
2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-1-oxoethyl]amino}-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / O-(1H-benzotriazol-1-yl)-N,N,N',N'-(Me₄)uronium⁽¹⁺⁾ BF₄^(1-); 1-HO-1H-benzotriazole (HOBt); Et₃N / acetonitrile / 22 h / 20 °C

2: 54 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 20 h / 20 °C

3: 65 percent / acetonitrile / 17 h / 20 °C

4: 93 percent / 3N HCl / tetrahydrofuran / 45 h / 20 °C / and 40 deg C, 6 h

With hydrogenchloride; lithium hydroxide; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; methanol; water; acetonitrile; 1: Condensation / 2: Hydrolysis / 3: Addition / 4: Hydrolysis;
DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G

Reference yield:

: 304682-72-2
2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoic acid

: 304682-74-4
2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-1-oxoethyl]amino}-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / acetonitrile / 17 h / 20 °C

2: 93 percent / 3N HCl / tetrahydrofuran / 45 h / 20 °C / and 40 deg C, 6 h

With hydrogenchloride; In tetrahydrofuran; acetonitrile; 1: Addition / 2: Hydrolysis;
DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G