Diisopropyl-phosphoramidous acid benzyl ester (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

Base Information

• Chemical Name: Diisopropyl-phosphoramidous acid benzyl ester (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
• CAS No.: 214068-63-0
• Molecular Formula: C₁₉H₃₂NO₄P
• Molecular Weight: 369.441

Synonyms:Diisopropyl-phosphoramidous acid benzyl ester (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

Chemical Property of Diisopropyl-phosphoramidous acid benzyl ester (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

Chemical Property:

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Technology Process of Diisopropyl-phosphoramidous acid benzyl ester (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

There total 3 articles about Diisopropyl-phosphoramidous acid benzyl ester (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite (108549-21-9) + 1,2-O-isopropylidene-D-glycerol (14347-78-5,36543-79-0) → Diisopropyl-phosphoramidous acid benzyl ester (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester (214068-63-0)

Guidance literature:

With terazole; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2007.01.095

Reference yield:

bis(diisopropylamino)chlorophosphine (56183-63-2) → Diisopropyl-phosphoramidous acid benzyl ester (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester (214068-63-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N

2: 95 percent / terazole / CH₂Cl₂ / 0.5 h / 20 °C

With terazole; triethylamine; In dichloromethane;

DOI:10.1016/j.tetlet.2007.01.095

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → Diisopropyl-phosphoramidous acid benzyl ester (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester (214068-63-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N

2: 95 percent / terazole / CH₂Cl₂ / 0.5 h / 20 °C

With terazole; triethylamine; In dichloromethane;

DOI:10.1016/j.tetlet.2007.01.095

upstream raw materials:

benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite

1,2-O-isopropylidene-D-glycerol

bis(diisopropylamino)chlorophosphine

benzyl alcohol

Downstream raw materials:

Phosphoric acid benzyl ester (1S,2R,3S,4S,5R,6R)-3,4-bis-benzyloxy-2,6-bis-benzyloxymethoxy-5-(bis-benzyloxy-phosphoryloxy)-cyclohexyl ester (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

Phosphoric acid benzyl ester (1R,2R,3S,4R,5R,6R)-3,4-bis-benzyloxy-2,6-bis-benzyloxymethoxy-5-hydroxy-cyclohexyl ester (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

Phosphoric acid benzyl ester (1S,2R,3S,4S,5R,6R)-3,4-bis-benzyloxy-2,6-bis-benzyloxymethoxy-5-(4-methoxy-benzyloxy)-cyclohexyl ester (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

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