Technology Process of Phosphoric acid benzyl ester (1S,2R,3S,4S,5R,6R)-3,4-bis-benzyloxy-2,6-bis-benzyloxymethoxy-5-(4-methoxy-benzyloxy)-cyclohexyl ester (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
There total 15 articles about Phosphoric acid benzyl ester (1S,2R,3S,4S,5R,6R)-3,4-bis-benzyloxy-2,6-bis-benzyloxymethoxy-5-(4-methoxy-benzyloxy)-cyclohexyl ester (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: proton sponge, n-Bu4NBr / acetonitrile / rt to 55 deg C
2: aq. NaOH / methanol / 2 h / Heating
3: 1.) 1H-tetrazole, 2.) m-CPBA / 1.) CH2Cl2, rt, 30 min, 2.) -40 deg C to rt, 60 min
With
1H-tetrazole; sodium hydroxide; Proton Sponge; tetrabutylammomium bromide; 3-chloro-benzenecarboperoxoic acid;
In
methanol; acetonitrile;
DOI:10.1021/jo980501r
- Guidance literature:
-
Multi-step reaction with 9 steps
1: NaH / dimethylformamide / 2 h / Ambient temperature
2: p-TsOH monohydrate / methanol / 1 h / Ambient temperature
3: (COCl)2, Et3N / CH2Cl2; dimethylsulfoxide / -78 deg C to rt
4: K2CO3 / acetonitrile / Heating; overnight
5: 1.) Hg(OAc)2, 2.) NaCl / 1.) acetone, H2O, 45 min, 2.) rt, 24 h
6: 81 percent / NaBH(OAc)3 / acetonitrile; acetic acid / 0.75 h / Ambient temperature
7: proton sponge, n-Bu4NBr / acetonitrile / rt to 55 deg C
8: aq. NaOH / methanol / 2 h / Heating
9: 1.) 1H-tetrazole, 2.) m-CPBA / 1.) CH2Cl2, rt, 30 min, 2.) -40 deg C to rt, 60 min
With
1H-tetrazole; sodium hydroxide; oxalyl dichloride; Proton Sponge; mercury(II) diacetate; tetrabutylammomium bromide; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium chloride;
In
methanol; dichloromethane; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo980501r
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 84 percent / diisopropylammonium tetrazole / CH2Cl2 / 1 h / Ambient temperature
2: 1.) 1H-tetrazole, 2.) m-CPBA / 1.) CH2Cl2, rt, 30 min, 2.) -40 deg C to rt, 60 min
With
1H-tetrazole; N,N-diisopropylamine tetrazolide; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
DOI:10.1021/jo980501r
