(S)-2-tert-Butoxycarbonylamino-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester

Base Information

• Chemical Name: (S)-2-tert-Butoxycarbonylamino-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester
• CAS No.: 187977-10-2
• Molecular Formula: C₁₈H₂₂Cl₃NO₆
• Molecular Weight: 454.735

Synonyms:(S)-2-tert-Butoxycarbonylamino-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester

Chemical Property of (S)-2-tert-Butoxycarbonylamino-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester

Chemical Property:

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Technology Process of (S)-2-tert-Butoxycarbonylamino-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester

There total 1 articles about (S)-2-tert-Butoxycarbonylamino-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1,1,1-trichloroethanol (115-20-8) + BOC-L-aspartic acid 4-benzyl ester (7536-58-5,98482-77-0) → (S)-2-tert-Butoxycarbonylamino-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester (187977-10-2)

Guidance literature:

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; 1.) 0 deg C, 3 h, 2.) room temperature, 21 h;

DOI:10.1021/jo961696a DOI:10.1021/jo961778z

Reference yield: 100.0%

(S)-2-tert-Butoxycarbonylamino-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester (187977-10-2) → (S)-2-Amino-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester (187977-11-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 0.75h; Ambient temperature;

DOI:10.1021/jo961778z

Reference yield: 100.0%

trifluoroacetic acid (76-05-1) + (S)-2-tert-Butoxycarbonylamino-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester (187977-10-2) → (S)-2-Amino-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester; compound with trifluoro-acetic acid

Guidance literature:

In dichloromethane; for 0.75h; Ambient temperature;

DOI:10.1021/jo961696a

upstream raw materials:

1,1,1-trichloroethanol

BOC-L-aspartic acid 4-benzyl ester

Downstream raw materials:

(S)-2-Amino-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester

(S)-2-[2-(2-{(S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester

(S)-2-[2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester

C₄₅H₅₃N₇O₁₀

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