2-(2,4-bis(benzyloxy)phenyl)-5-hydroxy-7-(methoxymethoxy)-3-(3-methyl-2-buten-1-yl)-4H-chromen-4-one

Base Information

Chemical Name:2-(2,4-bis(benzyloxy)phenyl)-5-hydroxy-7-(methoxymethoxy)-3-(3-methyl-2-buten-1-yl)-4H-chromen-4-one
CAS No.:1610962-13-4
Molecular Formula:C₃₆H₃₄O₇
Molecular Weight:578.662
Hs Code.:

Synonyms:2-(2,4-bis(benzyloxy)phenyl)-5-hydroxy-7-(methoxymethoxy)-3-(3-methyl-2-buten-1-yl)-4H-chromen-4-one

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Chemical Property of 2-(2,4-bis(benzyloxy)phenyl)-5-hydroxy-7-(methoxymethoxy)-3-(3-methyl-2-buten-1-yl)-4H-chromen-4-one

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Technology Process of 2-(2,4-bis(benzyloxy)phenyl)-5-hydroxy-7-(methoxymethoxy)-3-(3-methyl-2-buten-1-yl)-4H-chromen-4-one

There total 9 articles about 2-(2,4-bis(benzyloxy)phenyl)-5-hydroxy-7-(methoxymethoxy)-3-(3-methyl-2-buten-1-yl)-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1610962-14-5
1-(2,4-bis(benzyloxy)phenyl)-3-(2-hydroxy-4,6-bis(methoxymethoxy)phenyl)-2-(3-methyl-2-buten-1-yl)propane-1,3-dione

: 1610962-13-4
2-(2,4-bis(benzyloxy)phenyl)-5-hydroxy-7-(methoxymethoxy)-3-(3-methyl-2-buten-1-yl)-4H-chromen-4-one

: 1610962-12-3
2-(2,4-bis(benzyloxy)phenyl)-5,7-dihydroxy-3-(3-methyl-2-buten-1-yl)-4H-chromen-4-one

Guidance literature:: With chloro-trimethyl-silane; copper dichloride; In acetonitrile; at 20 ℃; for 0.5h;
DOI:10.1016/j.tet.2014.04.089

Reference yield:

: 65490-09-7
2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone

: 1610962-13-4
2-(2,4-bis(benzyloxy)phenyl)-5-hydroxy-7-(methoxymethoxy)-3-(3-methyl-2-buten-1-yl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 1 h / Reflux

3.1: potassium carbonate / acetone / 0.17 h

3.2: 2 h / 50 °C

4.1: copper dichloride; chloro-trimethyl-silane / acetonitrile / 0.5 h / 20 °C

With dmap; chloro-trimethyl-silane; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; copper dichloride; In tetrahydrofuran; dichloromethane; acetone; acetonitrile; 2.1: |Baker-Venkataraman Rearrangement;
DOI:10.1016/j.tet.2014.04.089

Reference yield:

: 1610962-15-6
1-(2,4-bis(benzyloxy)phenyl)-3-(2-hydroxy-4,6-bis(methoxymethoxy)phenyl)propane-1,3-dione

: 1610962-13-4
2-(2,4-bis(benzyloxy)phenyl)-5-hydroxy-7-(methoxymethoxy)-3-(3-methyl-2-buten-1-yl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 0.17 h

1.2: 2 h / 50 °C

2.1: copper dichloride; chloro-trimethyl-silane / acetonitrile / 0.5 h / 20 °C

With chloro-trimethyl-silane; potassium carbonate; copper dichloride; In acetone; acetonitrile;
DOI:10.1016/j.tet.2014.04.089