1-(2,4-bis(benzyloxy)phenyl)-3-(2-hydroxy-4,6-bis(methoxymethoxy)phenyl)-2-(3-methyl-2-buten-1-yl)propane-1,3-dione

Base Information

Chemical Name:1-(2,4-bis(benzyloxy)phenyl)-3-(2-hydroxy-4,6-bis(methoxymethoxy)phenyl)-2-(3-methyl-2-buten-1-yl)propane-1,3-dione
CAS No.:1610962-14-5
Molecular Formula:C₃₈H₄₀O₉
Molecular Weight:640.73
Hs Code.:

Synonyms:1-(2,4-bis(benzyloxy)phenyl)-3-(2-hydroxy-4,6-bis(methoxymethoxy)phenyl)-2-(3-methyl-2-buten-1-yl)propane-1,3-dione

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Chemical Property of 1-(2,4-bis(benzyloxy)phenyl)-3-(2-hydroxy-4,6-bis(methoxymethoxy)phenyl)-2-(3-methyl-2-buten-1-yl)propane-1,3-dione

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Technology Process of 1-(2,4-bis(benzyloxy)phenyl)-3-(2-hydroxy-4,6-bis(methoxymethoxy)phenyl)-2-(3-methyl-2-buten-1-yl)propane-1,3-dione

There total 8 articles about 1-(2,4-bis(benzyloxy)phenyl)-3-(2-hydroxy-4,6-bis(methoxymethoxy)phenyl)-2-(3-methyl-2-buten-1-yl)propane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1610962-15-6
1-(2,4-bis(benzyloxy)phenyl)-3-(2-hydroxy-4,6-bis(methoxymethoxy)phenyl)propane-1,3-dione

: 870-63-3
prenyl bromide

: 1610962-14-5
1-(2,4-bis(benzyloxy)phenyl)-3-(2-hydroxy-4,6-bis(methoxymethoxy)phenyl)-2-(3-methyl-2-buten-1-yl)propane-1,3-dione

Guidance literature:: 1-(2,4-bis(benzyloxy)phenyl)-3-(2-hydroxy-4,6-bis(methoxymethoxy)phenyl)propane-1,3-dione; With potassium carbonate; In acetone; for 0.166667h;

prenyl bromide; In acetone; at 50 ℃; for 2h;
DOI:10.1016/j.tet.2014.04.089

Reference yield:

: 65490-09-7
2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone

: 1610962-14-5
1-(2,4-bis(benzyloxy)phenyl)-3-(2-hydroxy-4,6-bis(methoxymethoxy)phenyl)-2-(3-methyl-2-buten-1-yl)propane-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 1 h / Reflux

3.1: potassium carbonate / acetone / 0.17 h

3.2: 2 h / 50 °C

With dmap; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; acetone; 2.1: |Baker-Venkataraman Rearrangement;
DOI:10.1016/j.tet.2014.04.089

Reference yield:

: 89-86-1
4-hydroxysalicylic acid

: 1610962-14-5
1-(2,4-bis(benzyloxy)phenyl)-3-(2-hydroxy-4,6-bis(methoxymethoxy)phenyl)-2-(3-methyl-2-buten-1-yl)propane-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / 24 h / Reflux

2.1: sodium hydroxide; water / methanol / 12 h / Reflux

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 1 h / Reflux

5.1: potassium carbonate / acetone / 0.17 h

5.2: 2 h / 50 °C

With dmap; water; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetone; 4.1: |Baker-Venkataraman Rearrangement;
DOI:10.1016/j.tet.2014.04.089