Chemical Property of Reboxetine mesylate
Chemical Property:
- Appearance/Colour:tan or off-white cyrstalline solid
- Vapor Pressure:4.54E-08mmHg at 25°C
- Melting Point:170-171°C
- Boiling Point:443.7 °C at 760 mmHg
- Flash Point:188.2 °C
- PSA：102.47000
- LogP:4.10740
- Storage Temp.:2-8°C
- Solubility.:H2O: ~8 mg/mL at ≤60 °C
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:6
- Exact Mass:409.15590875
- Heavy Atom Count:28
- Complexity:425
- Purity/Quality:
-
99%, *data from raw suppliers
ReboxetineMesylate *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
22-24/25
- MSDS Files:
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Useful:
- Canonical SMILES:CCOC1=CC=CC=C1OC(C2CNCCO2)C3=CC=CC=C3.CS(=O)(=O)O
- Isomeric SMILES:CCOC1=CC=CC=C1O[C@@H]([C@H]2CNCCO2)C3=CC=CC=C3.CS(=O)(=O)O
- Recent EU Clinical Trials:Crossover, Double-blind, Phase 2 Study of a Fixed Dose Combination of Reboxetine\\Oxybutynin (AD128) Versus Placebo in Obstructive Sleep Apnea (RebOx)
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Uses
A selective noradrenaline reuptake inhibitor. Antidepressant. Reboxetine mesylate hydrate has been used as a selective norepinephrine transport blocker:to study its effects on the surge of dopamine in the cortex of mice brainto study its anti-immobility effects on the behavior of miceto analyze its effects on the probabilistic reversal learning task in rodents
