2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

Base Information

Chemical Name:2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
CAS No.:1257341-56-2
Molecular Formula:C₃₅H₄₄FN₃O₆S
Molecular Weight:653.815
Hs Code.:

2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

Synonyms:2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

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Chemical Property of 2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

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Technology Process of 2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

There total 6 articles about 2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1257341-69-7
2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-2,2-dimethyl-6-((1-phenyl-1H-tetrazol-5-ylsulfonyl)methyl)-1,3-dioxan-4-yl)acetate

: 147118-37-4
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

: 1257341-56-2
2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2.16667h; Inert atmosphere;

Reference yield:

: 151-05-3
1,1-dimethyl-2-phenylethyl acetate

: 1257341-56-2
2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.67 h / -75 °C / Inert atmosphere

1.2: 5.33 h / 0 °C / Inert atmosphere

2.1: diethyl methoxy borane / tetrahydrofuran; methanol / 1 h / -75 °C

2.2: 5 h

2.3: 0.5 h

3.1: methanesulfonic acid / acetone / 2 h / 20 °C

4.1: N,N-dimethyl-formamide / 24 h / 90 °C

5.1: dihydrogen peroxide; hexaammonium heptamolybdate tetrahydrate / di-iso-propyl alcohol / 30 h / 0 - 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 2.17 h / -78 °C / Inert atmosphere

With methanesulfonic acid; hexaammonium heptamolybdate tetrahydrate; diethyl methoxy borane; dihydrogen peroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; di-iso-propyl alcohol; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1257341-61-9
2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

: 1257341-56-2
2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 24 h / 90 °C

2: dihydrogen peroxide; hexaammonium heptamolybdate tetrahydrate / di-iso-propyl alcohol / 30 h / 0 - 20 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 2.17 h / -78 °C / Inert atmosphere

With hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide; lithium hexamethyldisilazane; In tetrahydrofuran; di-iso-propyl alcohol; N,N-dimethyl-formamide;