2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

Base Information

• Chemical Name: 2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
• CAS No.: 1257341-56-2
• Molecular Formula: C₃₅H₄₄FN₃O₆S
• Molecular Weight: 653.815
• Mol file: 1257341-56-2.mol

Synonyms:2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

Chemical Property of 2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

There total 6 articles about 2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-2,2-dimethyl-6-((1-phenyl-1H-tetrazol-5-ylsulfonyl)methyl)-1,3-dioxan-4-yl)acetate (1257341-69-7) + N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide (147118-37-4) → 2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (1257341-56-2)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2.16667h; Inert atmosphere;

Reference yield:

1,1-dimethyl-2-phenylethyl acetate (151-05-3) → 2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (1257341-56-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.67 h / -75 °C / Inert atmosphere

1.2: 5.33 h / 0 °C / Inert atmosphere

2.1: diethyl methoxy borane / tetrahydrofuran; methanol / 1 h / -75 °C

2.2: 5 h

2.3: 0.5 h

3.1: methanesulfonic acid / acetone / 2 h / 20 °C

4.1: N,N-dimethyl-formamide / 24 h / 90 °C

5.1: dihydrogen peroxide; hexaammonium heptamolybdate tetrahydrate / di-iso-propyl alcohol / 30 h / 0 - 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 2.17 h / -78 °C / Inert atmosphere

With methanesulfonic acid; hexaammonium heptamolybdate tetrahydrate; diethyl methoxy borane; dihydrogen peroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; di-iso-propyl alcohol; N,N-dimethyl-formamide; acetone;

Reference yield:

2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (1257341-61-9) → 2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopronyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (1257341-56-2)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 24 h / 90 °C

2: dihydrogen peroxide; hexaammonium heptamolybdate tetrahydrate / di-iso-propyl alcohol / 30 h / 0 - 20 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 2.17 h / -78 °C / Inert atmosphere

With hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide; lithium hexamethyldisilazane; In tetrahydrofuran; di-iso-propyl alcohol; N,N-dimethyl-formamide;

upstream raw materials:

1,1-dimethyl-2-phenylethyl acetate

2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-2,2-dimethyl-6-((1-phenyl-1H-tetrazol-5-ylsulfonyl)methyl)-1,3-dioxan-4-yl)acetate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

Downstream raw materials:

rosuvastatin methylamine salt

Refernces

• 1、 -. "NOVEL METHOD FOR PREPARING ROSUVASTATIN, INTERMEDIATE COMPOUNDS USEFUL FOR PREPARING SAME, AND METHOD FOR PREPARING SAME". . . Retrieved 2012/06/16.