(2R,3S)-2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-1H-indol-3-yl)propanamide

Base Information

Chemical Name:(2R,3S)-2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-1H-indol-3-yl)propanamide
CAS No.:1433050-31-7
Molecular Formula:C₂₃H₁₈F₃N₃O₄
Molecular Weight:457.409
Hs Code.:

Synonyms:(2R,3S)-2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-1H-indol-3-yl)propanamide

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Chemical Property of (2R,3S)-2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-1H-indol-3-yl)propanamide

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Technology Process of (2R,3S)-2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-1H-indol-3-yl)propanamide

There total 5 articles about (2R,3S)-2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-1H-indol-3-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433051-80-9
(2R,3S)-ethyl 2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)-phenyl)-1H-indol-3-yl)propanoate

: 1433050-31-7
(2R,3S)-2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-1H-indol-3-yl)propanamide

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 72h;

Reference yield:

: 106-41-2
4-bromo-phenol

: 1433050-31-7
(2R,3S)-2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-1H-indol-3-yl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 14 h / 80 °C / Inert atmosphere

2: copper(l) iodide; potassium carbonate; dimethylaminoacetic acid / N,N-dimethyl-formamide / 0.5 h / 160 °C / Microwave irradiation

3: water; methanesulfonamide; AD-mix α / isopropyl alcohol / 4 h / 20 °C

4: ammonia / methanol / 72 h / 20 °C

With copper(l) iodide; dimethylaminoacetic acid; methanesulfonamide; AD-mix α; ammonia; water; potassium carbonate; In methanol; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1433050-31-7
(2R,3S)-2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-1H-indol-3-yl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 14 h / 80 °C / Inert atmosphere

2: copper(l) iodide; potassium carbonate; dimethylaminoacetic acid / N,N-dimethyl-formamide / 0.5 h / 160 °C / Microwave irradiation

3: water; methanesulfonamide; AD-mix α / isopropyl alcohol / 4 h / 20 °C

4: ammonia / methanol / 72 h / 20 °C

With copper(l) iodide; dimethylaminoacetic acid; methanesulfonamide; AD-mix α; ammonia; water; potassium carbonate; In methanol; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;