(2R,3S)-ethyl 2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)-phenyl)-1H-indol-3-yl)propanoate

Base Information

Chemical Name:(2R,3S)-ethyl 2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)-phenyl)-1H-indol-3-yl)propanoate
CAS No.:1433051-80-9
Molecular Formula:C₂₅H₂₁F₃N₂O₅
Molecular Weight:486.447
Hs Code.:

Synonyms:(2R,3S)-ethyl 2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)-phenyl)-1H-indol-3-yl)propanoate

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Chemical Property of (2R,3S)-ethyl 2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)-phenyl)-1H-indol-3-yl)propanoate

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Technology Process of (2R,3S)-ethyl 2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)-phenyl)-1H-indol-3-yl)propanoate

There total 5 articles about (2R,3S)-ethyl 2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)-phenyl)-1H-indol-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433051-75-2
(E)-ethyl 3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-1H-indol-3-yl)acrylate

: 1433051-80-9
(2R,3S)-ethyl 2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)-phenyl)-1H-indol-3-yl)propanoate

Guidance literature:: With methanesulfonamide; AD-mix α; water; In isopropyl alcohol; at 20 ℃; for 4h;

Reference yield:

: 106-41-2
4-bromo-phenol

: 1433051-80-9
(2R,3S)-ethyl 2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)-phenyl)-1H-indol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 14 h / 80 °C / Inert atmosphere

2: copper(l) iodide; potassium carbonate; dimethylaminoacetic acid / N,N-dimethyl-formamide / 0.5 h / 160 °C / Microwave irradiation

3: water; methanesulfonamide; AD-mix α / isopropyl alcohol / 4 h / 20 °C

With copper(l) iodide; dimethylaminoacetic acid; methanesulfonamide; AD-mix α; water; potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1433051-80-9
(2R,3S)-ethyl 2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)-phenyl)-1H-indol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 14 h / 80 °C / Inert atmosphere

2: copper(l) iodide; potassium carbonate; dimethylaminoacetic acid / N,N-dimethyl-formamide / 0.5 h / 160 °C / Microwave irradiation

3: water; methanesulfonamide; AD-mix α / isopropyl alcohol / 4 h / 20 °C

With copper(l) iodide; dimethylaminoacetic acid; methanesulfonamide; AD-mix α; water; potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;