4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine methyl ester

Base Information

Chemical Name:4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine methyl ester
CAS No.:1261154-06-6
Molecular Formula:C₂₈H₃₀NO₈P
Molecular Weight:539.522
Hs Code.:

Synonyms:4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine methyl ester

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Chemical Property of 4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine methyl ester

Chemical Property:

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Technology Process of 4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine methyl ester

There total 9 articles about 4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₂₀NO₆P

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 1261154-06-6
4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine methyl ester

Guidance literature:: With sodium hydrogencarbonate; In water; acetonitrile; at 20 ℃;
DOI:10.1016/j.bmc.2010.09.040

Reference yield:

: 183021-88-7
methyl 2-{[(benzyloxy)carbonyl]amino}-3-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)propanoate

: 1261154-06-6
4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere

2: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

3: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 1 h

4: cesium fluoride / 1 h

5: hydrogen / palladium on activated charcoal / methanol / 6 h / 20 °C / Inert atmosphere

6: sodium hydrogencarbonate / acetonitrile; water / 20 °C

With dimethylsulfide borane complex; hydrogen; sodium hydrogencarbonate; potassium carbonate; cesium fluoride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; 1,1'-bis-(diphenylphosphino)ferrocene; palladium on activated charcoal; palladium diacetate; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 13512-31-7
N-(benzyloxycarbonyl)-L-tyrosine methyl ester

: 1261154-06-6
4-[(dimethyloxyphosphinyl)-hydroxymethyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / acetonitrile / 3 h / 20 °C / Inert atmosphere

2: potassium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere

3: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

4: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 1 h

5: cesium fluoride / 1 h

6: hydrogen / palladium on activated charcoal / methanol / 6 h / 20 °C / Inert atmosphere

7: sodium hydrogencarbonate / acetonitrile; water / 20 °C

With dimethylsulfide borane complex; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; cesium fluoride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; 1,1'-bis-(diphenylphosphino)ferrocene; palladium on activated charcoal; palladium diacetate; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;