tert-butyl 2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate

Base Information

Chemical Name:tert-butyl 2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate
CAS No.:351370-97-3
Molecular Formula:C₁₉H₂₈N₂O₂
Molecular Weight:316.444
Hs Code.:

Synonyms:tert-butyl 2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate

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Chemical Property of tert-butyl 2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of tert-butyl 2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate

There total 5 articles about tert-butyl 2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4664-08-8
cinchomeronic anhydride

: 351370-97-3
tert-butyl 2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: acetic anhydride / 1 h / 0 - 20 °C / Reflux

2: acetic anhydride / 4 h / 110 °C

3: palladium on carbon; hydrogen / methanol / 60 °C / 22502.3 Torr

4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere; Reflux

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; palladium on carbon; hydrogen; acetic anhydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 100-39-0
benzyl bromide

: 351370-97-3
tert-butyl 2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / acetone / 5 h / Reflux

2: hydrogen; palladium 10% on activated carbon / 2-methoxy-ethanol / 6 h / 35 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 °C / Reflux; Inert atmosphere

4: sodium carbonate / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 2-methoxy-ethanol; acetone;

Reference yield:

: 4664-01-1
3,4-pyridinedicarboximide

: 351370-97-3
tert-butyl 2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / acetone / 5 h / Reflux

2: hydrogen; palladium 10% on activated carbon / 2-methoxy-ethanol / 6 h / 35 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 °C / Reflux; Inert atmosphere

4: sodium carbonate / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 2-methoxy-ethanol; acetone;