ethyl-3--L-Phe-L-(Tr-Gln)>-E-propenoate

Base Information

Chemical Name:ethyl-3--L-Phe-L-(Tr-Gln)>-E-propenoate
CAS No.:214286-97-2
Molecular Formula:C₄₉H₅₉N₃O₇
Molecular Weight:802.023
Hs Code.:

ethyl-3-<Boc-L-tBuGlyΨ<COCH2>-L-Phe-L-(Tr-Gln)>-E-propenoate

Synonyms:ethyl-3--L-Phe-L-(Tr-Gln)>-E-propenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl-3--L-Phe-L-(Tr-Gln)>-E-propenoate

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Technology Process of ethyl-3--L-Phe-L-(Tr-Gln)>-E-propenoate

There total 9 articles about ethyl-3--L-Phe-L-(Tr-Gln)>-E-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 214286-96-1
Boc-L-tBuGlyΨ-L-Phe-OH

: ethyl-3--E-propenoate hydrochloride

: 214286-97-2
ethyl-3--L-Phe-L-(Tr-Gln)>-E-propenoate

Guidance literature:: With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 23 ℃;
DOI:10.1021/jm980537b

Reference yield:

: 20859-02-3
L-tert-Leucine

: 214286-97-2
ethyl-3--L-Phe-L-(Tr-Gln)>-E-propenoate

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / 1.0 M aq. NaOH / dioxane / 18 h / 0 °C

2: 1.) LDA, 2.) 1,1'-carbonyldiimidazole / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, -78 deg C, 1 h

3: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₂Cl₂, 23 deg C, 24 h

4: TFA / CH₂Cl₂ / 24 h / 23 °C

5: 70 percent / H₂ / 10 percent Pd/C / methanol / 23 °C

6: 99 percent / 2.0 M NaOH / methanol / 2 h / 0 °C

7: 70 percent / 4-methymorpholine, 1-hydroxybenzotriazole hydrate, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 23 °C

With 4-methyl-morpholine; sodium hydroxide; hydrogen; sodium hydride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1'-carbonyldiimidazole; trifluoroacetic acid; lithium diisopropyl amide; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm980537b

Reference yield:

: 62965-10-0
(S)-N-carbobenzoxy-tert-butylleucine

: 214286-97-2
ethyl-3--L-Phe-L-(Tr-Gln)>-E-propenoate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LDA, 2.) 1,1'-carbonyldiimidazole / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, -78 deg C, 1 h

2: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₂Cl₂, 23 deg C, 24 h

3: TFA / CH₂Cl₂ / 24 h / 23 °C

4: 70 percent / H₂ / 10 percent Pd/C / methanol / 23 °C

5: 99 percent / 2.0 M NaOH / methanol / 2 h / 0 °C

6: 70 percent / 4-methymorpholine, 1-hydroxybenzotriazole hydrate, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 23 °C

With 4-methyl-morpholine; sodium hydroxide; hydrogen; sodium hydride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1'-carbonyldiimidazole; trifluoroacetic acid; lithium diisopropyl amide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm980537b