N-(5-(3-chloro-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)-4-fluorobenzenesulfonamide

Base Information

Chemical Name:N-(5-(3-chloro-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)-4-fluorobenzenesulfonamide
CAS No.:1609565-40-3
Molecular Formula:C₁₇H₁₂ClFN₆O₃S
Molecular Weight:434.838
Hs Code.:

Synonyms:N-(5-(3-chloro-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)-4-fluorobenzenesulfonamide

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Chemical Property of N-(5-(3-chloro-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)-4-fluorobenzenesulfonamide

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Technology Process of N-(5-(3-chloro-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)-4-fluorobenzenesulfonamide

There total 2 articles about N-(5-(3-chloro-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)-4-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 33050-38-3
3,6-dichloro-1,2,4-triazolo<4,3-b>pyridazine

: 4-fluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxyborolan-2-yl)pyridine-3-yl)benzenesulfonamide

: 1609565-40-3
N-(5-(3-chloro-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)-4-fluorobenzenesulfonamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,2-dimethoxyethane; water; at 70 ℃; for 12h; Inert atmosphere;

Reference yield:

: 33050-32-7
6-chloro-[1,2,4]-triazolo[4,3-b]pyridazin-3-ol

: 1609565-40-3
N-(5-(3-chloro-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)-4-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus pentachloride; trichlorophosphate / 12 h / 120 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / water; 1,2-dimethoxyethane / 12 h / 70 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; phosphorus pentachloride; caesium carbonate; trichlorophosphate; In 1,2-dimethoxyethane; water;

Reference yield: 68.0%

: 1609565-40-3
N-(5-(3-chloro-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)-4-fluorobenzenesulfonamide

: 115-19-5
2-methyl-but-3-yn-2-ol

: 1609565-39-0
4-fluoro-N-(5-(3-(3-hydroxy-3-methylbut-1-yn-1-yl)-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide

Guidance literature:: With diisopropylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In N,N-dimethyl-formamide; at 100 ℃; for 36h; Inert atmosphere;