4-fluoro-N-(5-(3-(3-hydroxy-3-methylbut-1-yn-1-yl)-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide

Base Information

Chemical Name:4-fluoro-N-(5-(3-(3-hydroxy-3-methylbut-1-yn-1-yl)-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide
CAS No.:1609565-39-0
Molecular Formula:C₂₂H₁₉FN₆O₄S
Molecular Weight:482.495
Hs Code.:

Synonyms:4-fluoro-N-(5-(3-(3-hydroxy-3-methylbut-1-yn-1-yl)-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide

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Chemical Property of 4-fluoro-N-(5-(3-(3-hydroxy-3-methylbut-1-yn-1-yl)-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide

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Technology Process of 4-fluoro-N-(5-(3-(3-hydroxy-3-methylbut-1-yn-1-yl)-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide

There total 3 articles about 4-fluoro-N-(5-(3-(3-hydroxy-3-methylbut-1-yn-1-yl)-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1609565-40-3
N-(5-(3-chloro-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)-4-fluorobenzenesulfonamide

: 115-19-5
2-methyl-but-3-yn-2-ol

: 1609565-39-0
4-fluoro-N-(5-(3-(3-hydroxy-3-methylbut-1-yn-1-yl)-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide

Guidance literature:: With diisopropylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In N,N-dimethyl-formamide; at 100 ℃; for 36h; Inert atmosphere;

Reference yield:

: 33050-32-7
6-chloro-[1,2,4]-triazolo[4,3-b]pyridazin-3-ol

: 1609565-39-0
4-fluoro-N-(5-(3-(3-hydroxy-3-methylbut-1-yn-1-yl)-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus pentachloride; trichlorophosphate / 12 h / 120 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / water; 1,2-dimethoxyethane / 12 h / 70 °C / Inert atmosphere

3: diisopropylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide / 36 h / 100 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; phosphorus pentachloride; caesium carbonate; diisopropylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; trichlorophosphate; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 33050-38-3
3,6-dichloro-1,2,4-triazolo<4,3-b>pyridazine

: 1609565-39-0
4-fluoro-N-(5-(3-(3-hydroxy-3-methylbut-1-yn-1-yl)-[1,2,4]-triazolo[4,3-b]pyridazin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / water; 1,2-dimethoxyethane / 12 h / 70 °C / Inert atmosphere

2: diisopropylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide / 36 h / 100 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; diisopropylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;