2-(1,3-dioxan-2-yl)-3-benzoyloxyphenyl-4-ethyl-O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite

Base Information

Chemical Name:2-(1,3-dioxan-2-yl)-3-benzoyloxyphenyl-4-ethyl-O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite
CAS No.:364777-45-7
Molecular Formula:C₂₈H₃₇N₂O₆P
Molecular Weight:528.585
Hs Code.:

Synonyms:2-(1,3-dioxan-2-yl)-3-benzoyloxyphenyl-4-ethyl-O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite

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Chemical Property of 2-(1,3-dioxan-2-yl)-3-benzoyloxyphenyl-4-ethyl-O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite

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Technology Process of 2-(1,3-dioxan-2-yl)-3-benzoyloxyphenyl-4-ethyl-O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite

There total 6 articles about 2-(1,3-dioxan-2-yl)-3-benzoyloxyphenyl-4-ethyl-O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 364777-44-6
3-(1,3-dioxan-2-yl)-4-benzoyloxy-benzeneethanol

: 364777-45-7
2-(1,3-dioxan-2-yl)-3-benzoyloxyphenyl-4-ethyl-O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite

Guidance literature:: With (i-Pr)2NH₂*CHN₄; In dichloromethane; for 0.5h;
DOI:10.1021/ja0162212

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 364777-45-7
2-(1,3-dioxan-2-yl)-3-benzoyloxyphenyl-4-ethyl-O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / hexadecyltributylphosphonium bromide; HBr / 7.5 h / Heating

2: 88 percent / LiAlH₄ / tetrahydrofuran / 2.5 h / 67 °C

3: 33 percent / trifluoroacetic acid / 2.75 h / Heating

4: 50 percent / acidic alumina / toluene / 24 h / Heating

5: 68 percent / aq. NaOH / tetrahydrofuran / 0.03 h

6: 96 percent / (i-Pr)2NH₂*CHN₄ / CH₂Cl₂ / 0.5 h

With sodium hydroxide; lithium aluminium tetrahydride; (i-Pr)2NH₂*CHN₄; hydrogen bromide; cetyltributylphosphonium bromide; trifluoroacetic acid; aluminum oxide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ja0162212

Reference yield:

: 156-38-7
4-hydroxyphenylacetate

: 364777-45-7
2-(1,3-dioxan-2-yl)-3-benzoyloxyphenyl-4-ethyl-O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / LiAlH₄ / tetrahydrofuran / 2.5 h / 67 °C

2: 33 percent / trifluoroacetic acid / 2.75 h / Heating

3: 50 percent / acidic alumina / toluene / 24 h / Heating

4: 68 percent / aq. NaOH / tetrahydrofuran / 0.03 h

5: 96 percent / (i-Pr)2NH₂*CHN₄ / CH₂Cl₂ / 0.5 h

With sodium hydroxide; lithium aluminium tetrahydride; (i-Pr)2NH₂*CHN₄; trifluoroacetic acid; aluminum oxide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ja0162212