dimethyl (5-{[(allyloxy)carbonyl]amino}pentyl)(5-{[(benzyloxy)carbonyl]amino}pentyl)malonate

Base Information

Chemical Name:dimethyl (5-{[(allyloxy)carbonyl]amino}pentyl)(5-{[(benzyloxy)carbonyl]amino}pentyl)malonate
CAS No.:883981-58-6
Molecular Formula:C₂₇H₄₀N₂O₈
Molecular Weight:520.623
Hs Code.:

Synonyms:dimethyl (5-{[(allyloxy)carbonyl]amino}pentyl)(5-{[(benzyloxy)carbonyl]amino}pentyl)malonate

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Chemical Property of dimethyl (5-{[(allyloxy)carbonyl]amino}pentyl)(5-{[(benzyloxy)carbonyl]amino}pentyl)malonate

Chemical Property:

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Technology Process of dimethyl (5-{[(allyloxy)carbonyl]amino}pentyl)(5-{[(benzyloxy)carbonyl]amino}pentyl)malonate

There total 1 articles about dimethyl (5-{[(allyloxy)carbonyl]amino}pentyl)(5-{[(benzyloxy)carbonyl]amino}pentyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 883981-57-5
dimethyl (5-{[(benzyloxy)carbonyl]amino}pentyl)malonate

: 221303-08-8
allyl (5-bromopentyl)carbamate

: 883981-58-6
dimethyl (5-{[(allyloxy)carbonyl]amino}pentyl)(5-{[(benzyloxy)carbonyl]amino}pentyl)malonate

Guidance literature:: dimethyl (5-{[(benzyloxy)carbonyl]amino}pentyl)malonate; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

allyl (5-bromopentyl)carbamate; With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; for 12h; Heating;
DOI:10.1021/ja057664z

Reference yield: 66.0%

: 883981-58-6
dimethyl (5-{[(allyloxy)carbonyl]amino}pentyl)(5-{[(benzyloxy)carbonyl]amino}pentyl)malonate

: 883981-59-7
methyl 7-{[(allyloxy)carbonyl]amino}-2-(5-{[(benzyloxy)carbonyl]amino}pentyl)heptanoate

Guidance literature:: With water; lithium chloride; In dimethyl sulfoxide; at 160 ℃; for 4h;
DOI:10.1021/ja057664z

Reference yield:

: 883981-58-6
dimethyl (5-{[(allyloxy)carbonyl]amino}pentyl)(5-{[(benzyloxy)carbonyl]amino}pentyl)malonate

: 883981-66-6
(2E)-N-[6-(tert-butyldimethylsilyloxymethyl)-11-({4-oxo-4-[phenyl(pyridin-4-ylmethyl)amino]butanoyl}amino)undecyl]-N'-(2,2-diphenylethyl)but-2-enediamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: 66 percent / LiCl; water / dimethylsulfoxide / 4 h / 160 °C

2.1: 68 percent / diisobutylaluminum hydride / toluene; tetrahydrofuran / 4 h / -78 °C

3.1: phenylsilane; Pd(PPh₃)4 / CH₂Cl₂ / 0.75 h

4.1: 1.10 g / Et₃N / CH₂Cl₂ / 0.75 h

5.1: H₂; HCl / Pd/C / diethyl ether; methanol / atmospheric pressure

6.1: 1-[3-dimethylaminopropyl]-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate; triethylamine / CH₂Cl₂ / 0.5 h / 20 °C

6.2: 550 mg / triethylamine / CH₂Cl₂ / 4 h / 20 °C

7.1: 63 percent / imidazole / CH₂Cl₂ / 2 h

8.1: piperidine / tetrahydrofuran; acetonitrile / 2.5 h / 20 °C

9.1: 1-[3-dimethylaminopropyl]-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate; triethylamine / CH₂Cl₂ / 0.5 h / 20 °C

9.2: 20.0 mg / triethylamine / CH₂Cl₂; tetrahydrofuran / 14 h / 20 °C

With piperidine; 1H-imidazole; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylsilane; water; hydrogen; diisobutylaluminium hydride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1021/ja057664z