3-O-hexadecyl-2-O-palmitoyl-sn-glycerol 1-p-toluenesulfonate

Base Information

• Chemical Name: 3-O-hexadecyl-2-O-palmitoyl-sn-glycerol 1-p-toluenesulfonate
• CAS No.: 122470-18-2
• Molecular Formula: C₄₂H₇₆O₆S
• Molecular Weight: 709.128
• Mol file: 122470-18-2.mol

Synonyms:3-O-hexadecyl-2-O-palmitoyl-sn-glycerol 1-p-toluenesulfonate

Chemical Property of 3-O-hexadecyl-2-O-palmitoyl-sn-glycerol 1-p-toluenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-O-hexadecyl-2-O-palmitoyl-sn-glycerol 1-p-toluenesulfonate

There total 4 articles about 3-O-hexadecyl-2-O-palmitoyl-sn-glycerol 1-p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3‐hexadecyloxy‐2R‐hydroxyl propyl‐1‐p‐toluene sulphonate (119944-30-8) + n-hexadecanoyl chloride (112-67-4) → 3-O-hexadecyl-2-O-palmitoyl-sn-glycerol 1-p-toluenesulfonate (122470-18-2)

Guidance literature:

With pyridine; In hexane; for 4h; Heating;

DOI:10.1021/jo00280a035

Reference yield:

3-(hexadecyloxy)-1,2-propanediol (6145-69-3) → 3-O-hexadecyl-2-O-palmitoyl-sn-glycerol 1-p-toluenesulfonate (122470-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / DMAP, pyridine / 72 h / 0 °C

2: hexane; benzene / 48 h / 37 °C / Pseudomonas fluorescens lipase on Celite

With pyridine; dmap; In hexane; benzene;

DOI:10.1021/jo00057a015

Reference yield:

hexadecanyl bromide (112-82-3) → 3-O-hexadecyl-2-O-palmitoyl-sn-glycerol 1-p-toluenesulfonate (122470-18-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / tetrabutylammonium iodide, NaH / dimethylformamide / 24 h / Ambient temperature

2: 71 percent / DMAP, pyridine / 72 h / 0 °C

3: hexane; benzene / 48 h / 37 °C / Pseudomonas fluorescens lipase on Celite

With pyridine; dmap; tetra-(n-butyl)ammonium iodide; sodium hydride; In hexane; N,N-dimethyl-formamide; benzene;

DOI:10.1021/jo00057a015

upstream raw materials:

palmitic anhydride

(3-Hexadecyloxy-2-hydroxypropyl) p-toluenesulfonate

3‐hexadecyloxy‐2R‐hydroxyl propyl‐1‐p‐toluene sulphonate

n-hexadecanoyl chloride