thioacetic acid S-[(S)-3-(2-fluoro-5-nitro-phenyl)-(R)-3-(2-methyl-propane-2-sulfinylamino)-butyl] ester

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Chemical Name:thioacetic acid S-[(S)-3-(2-fluoro-5-nitro-phenyl)-(R)-3-(2-methyl-propane-2-sulfinylamino)-butyl] ester
CAS No.:1396787-83-9
Molecular Formula:C₁₆H₂₃FN₂O₄S₂
Molecular Weight:390.5
Hs Code.:

Synonyms:thioacetic acid S-[(S)-3-(2-fluoro-5-nitro-phenyl)-(R)-3-(2-methyl-propane-2-sulfinylamino)-butyl] ester

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Chemical Property of thioacetic acid S-[(S)-3-(2-fluoro-5-nitro-phenyl)-(R)-3-(2-methyl-propane-2-sulfinylamino)-butyl] ester

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Technology Process of thioacetic acid S-[(S)-3-(2-fluoro-5-nitro-phenyl)-(R)-3-(2-methyl-propane-2-sulfinylamino)-butyl] ester

There total 3 articles about thioacetic acid S-[(S)-3-(2-fluoro-5-nitro-phenyl)-(R)-3-(2-methyl-propane-2-sulfinylamino)-butyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346145-61-6
(R)-2-methyl-propane-2-sulfinic acid [(S)-1-(2-fluoro-5-nitro-phenyl)-3-hydroxy-1-methyl-propyl]-amide

: 507-09-5
tiolacetic acid

: 1396787-83-9
thioacetic acid S-[(S)-3-(2-fluoro-5-nitro-phenyl)-(R)-3-(2-methyl-propane-2-sulfinylamino)-butyl] ester

Guidance literature:: With bis(4-chlorobenzyl) diazene-1,2-dicarboxylate; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 18.33h; Inert atmosphere;

Reference yield:

: 79110-05-7
1-(2-fluoro-5-nitrophenyl)ethanone

: 1396787-83-9
thioacetic acid S-[(S)-3-(2-fluoro-5-nitro-phenyl)-(R)-3-(2-methyl-propane-2-sulfinylamino)-butyl] ester

Guidance literature:: Multi-step reaction with 4 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / 5 h / Reflux

2: zinc / tetrahydrofuran / 5.25 h / Inert atmosphere; Reflux

3: lithium borohydride / tetrahydrofuran / 4 h / 0 °C

4: triphenylphosphine; bis(4-chlorobenzyl) diazene-1,2-dicarboxylate / dichloromethane / 18.33 h / 0 - 20 °C / Inert atmosphere

With bis(4-chlorobenzyl) diazene-1,2-dicarboxylate; titanium(IV) tetraethanolate; lithium borohydride; triphenylphosphine; zinc; In tetrahydrofuran; dichloromethane; 2: Reformatsky Reaction / 4: Mitsunobu reaction;

Reference yield:

: 1075230-63-5
tert-butyl (S)-3-(((R)-tert-butylsulfinyl)amino)-3-(2-fluoro-5-nitrophenyl)butanoate

: 1396787-83-9
thioacetic acid S-[(S)-3-(2-fluoro-5-nitro-phenyl)-(R)-3-(2-methyl-propane-2-sulfinylamino)-butyl] ester

Guidance literature:: Multi-step reaction with 2 steps

1: lithium borohydride / tetrahydrofuran / 4 h / 0 °C

2: triphenylphosphine; bis(4-chlorobenzyl) diazene-1,2-dicarboxylate / dichloromethane / 18.33 h / 0 - 20 °C / Inert atmosphere

With bis(4-chlorobenzyl) diazene-1,2-dicarboxylate; lithium borohydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;