N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-2-(4-methoxyphenyl)isothiazolidine-5-carboxamide 1,1-dioxide

Base Information

Chemical Name:N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-2-(4-methoxyphenyl)isothiazolidine-5-carboxamide 1,1-dioxide
CAS No.:1318757-15-1
Molecular Formula:C₂₂H₂₁ClFN₃O₄S₂
Molecular Weight:510.01
Hs Code.:

Synonyms:N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-2-(4-methoxyphenyl)isothiazolidine-5-carboxamide 1,1-dioxide

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Chemical Property of N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-2-(4-methoxyphenyl)isothiazolidine-5-carboxamide 1,1-dioxide

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Technology Process of N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-2-(4-methoxyphenyl)isothiazolidine-5-carboxamide 1,1-dioxide

There total 8 articles about N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-2-(4-methoxyphenyl)isothiazolidine-5-carboxamide 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1318758-33-6
2-(4-methoxyphenyl)isothiazolidine-5-carboxylic acid 1,1-dioxide

: 1318757-72-0
tert-butyl [2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]carbamate

: 1318757-15-1
N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-2-(4-methoxyphenyl)isothiazolidine-5-carboxamide 1,1-dioxide

Guidance literature:: tert-butyl [2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]carbamate; With hydrogenchloride; In ethanol; water; at 50 ℃; for 2h;

With sodium hydrogencarbonate; sodium hydroxide; In ethanol; water; at 20 ℃; pH=10 - 11;

2-(4-methoxyphenyl)isothiazolidine-5-carboxylic acid 1,1-dioxide; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl acetamide; at 60 ℃; for 1h;

Reference yield:

: 104-94-9
4-methoxy-aniline

: 1318757-15-1
N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-2-(4-methoxyphenyl)isothiazolidine-5-carboxamide 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / acetonitrile / 0.33 h / 0 - 20 °C

1.2: 4 h / 60 °C

2.1: potassium hydroxide; water / methanol / 0.5 h / 20 °C

2.2: 20 °C

3.1: hydrogenchloride / ethanol; water / 2 h / 50 °C

3.2: 20 °C / pH 10 - 11

3.3: 1 h / 60 °C

With pyridine; hydrogenchloride; water; potassium hydroxide; In methanol; ethanol; water; acetonitrile;

Reference yield:

: 493038-93-0
(3-chloro-5-fluorophenyl)acetonitrile

: 1318757-15-1
N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-2-(4-methoxyphenyl)isothiazolidine-5-carboxamide 1,1-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate / ethyl acetate / 20 °C

2.1: pyridine / ethanol / 72 h / 20 °C

3.1: sodium hydroxide; water / ethanol / 3 h

4.1: triethylamine; diphenyl phosphoryl azide / 2.5 h / 90 °C

5.1: hydrogenchloride / ethanol; water / 2 h / 50 °C

5.2: 20 °C / pH 10 - 11

5.3: 1 h / 60 °C

With pyridine; hydrogenchloride; diphenyl phosphoryl azide; water; O,O-Diethyl hydrogen phosphorodithioate; triethylamine; sodium hydroxide; In ethanol; water; ethyl acetate;