Technology Process of (R)-1-((4R,5S,6R)-6-((2S,3S)-3-(tert-butyldiphenylsilyloxy)butan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)ethane-1,2-diol
There total 17 articles about (R)-1-((4R,5S,6R)-6-((2S,3S)-3-(tert-butyldiphenylsilyloxy)butan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)ethane-1,2-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C30H42O6Si;
With
lithium hydroxide; water;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 0.416667h;
With
ammonium chloride;
In
tetrahydrofuran; methanol; water;
DOI:10.1002/anie.200804645
- Guidance literature:
-
With
lithium hydroxide;
In
tetrahydrofuran; methanol; water;
at 20 ℃;
for 0.416667h;
DOI:10.1002/chem.201102797
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: lithium borohydride / tetrahydrofuran; diethyl ether; ethanol / 4.5 h / 0 - 20 °C / Inert atmosphere
2.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; potassium bromide / dichloromethane / 0 °C / pH 8.6 / aq. buffer
2.2: 0.42 h / 0 °C
3.1: hydroxylamine hydrochloride / pyridine; ethanol / 12.5 h / 20 °C / Inert atmosphere
4.1: dichloromethane / -78 °C / Inert atmosphere
4.2: 0 - 20 °C / Inert atmosphere
5.1: toluene-4-sulfonic acid / methanol / 1.75 h / 20 °C / Inert atmosphere
6.1: pyridine / dichloromethane / 0.17 h / -78 - 0 °C / Inert atmosphere
7.1: hydrogen; boric acid / methanol; water / 3 h / 20 °C
8.1: acetic acid; tetramethylammonium triacetoxyborohydride / acetonitrile / 118 h / -10 - -5 °C / Inert atmosphere
9.1: toluene-4-sulfonic acid / 0.33 h / 20 °C / Inert atmosphere
10.1: lithium hydroxide / tetrahydrofuran; methanol; water / 0.42 h / 20 °C
With
pyridine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; lithium borohydride; hydroxylamine hydrochloride; hydrogen; boric acid; toluene-4-sulfonic acid; acetic acid; potassium bromide; lithium hydroxide; tetramethylammonium triacetoxyborohydride;
In
tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1002/chem.201102797
