N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4S)-6-isopropoxy-3,4-dihydro-2H-chromen-4-yl]amino}propyl)acetamide

Base Information

Chemical Name:N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4S)-6-isopropoxy-3,4-dihydro-2H-chromen-4-yl]amino}propyl)acetamide
CAS No.:676134-45-5
Molecular Formula:C₂₄H₃₀F₂N₂O₄
Molecular Weight:448.51
Hs Code.:

Synonyms:N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4S)-6-isopropoxy-3,4-dihydro-2H-chromen-4-yl]amino}propyl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4S)-6-isopropoxy-3,4-dihydro-2H-chromen-4-yl]amino}propyl)acetamide

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Technology Process of N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4S)-6-isopropoxy-3,4-dihydro-2H-chromen-4-yl]amino}propyl)acetamide

There total 9 articles about N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4S)-6-isopropoxy-3,4-dihydro-2H-chromen-4-yl]amino}propyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 2466-76-4
N-Acetylimidazole

: (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[(4S)-6-isopropoxy-3,4-dihydro-2H-chromen-4-yl]amino}butan-2-ol hydrochloride

: 676134-45-5
N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4S)-6-isopropoxy-3,4-dihydro-2H-chromen-4-yl]amino}propyl)acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 777056-99-2
C₂₂H₂₈F₂N₂O₃

: 64-19-7,77671-22-8
acetic acid

: 676134-45-5
N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4S)-6-isopropoxy-3,4-dihydro-2H-chromen-4-yl]amino}propyl)acetamide

Guidance literature:: With benzotriazol-1-ol; 4-methylmorpholine N-oxide; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2013.06.006

Reference yield:

: C₁₂H₁₆O₃

: 676134-45-5
N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4S)-6-isopropoxy-3,4-dihydro-2H-chromen-4-yl]amino}propyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

3: sodium hydroxide / isopropyl alcohol / 85 °C

4: hydrogenchloride / 1,4-dioxane / 0 - 20 °C

5: benzotriazol-1-ol; 4-methylmorpholine N-oxide / dichloromethane / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; diphenyl phosphoryl azide; benzotriazol-1-ol; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; isopropyl alcohol; toluene;
DOI:10.1016/j.bmcl.2013.06.006