777056-99-2Relevant academic research and scientific papers
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Prime side chromane-containing inhibitors
Ng, Raymond A.,Sun, Minghua,Bowers, Simeon,Hom, Roy K.,Probst, Gary D.,John, Varghese,Fang, Lawrence Y.,Maillard, Michel,Gailunas, Andrea,Brogley, Louis,Neitz, R. Jeffrey,Tung, Jay S.,Pleiss, Michael A.,Konradi, Andrei W.,Sham, Hing L.,Dappen, Michael S.,Adler, Marc,Yao, Nanhua,Zmolek, Wes,Nakamura, David,Quinn, Kevin P.,Sauer, John-Michael,Bova, Michael P.,Ruslim, Lany,Artis, Dean R.,Yednock, Ted A.
, p. 4674 - 4679 (2013/08/23)
The structure activity relationship of the prime region of conformationally restricted hydroxyethylamine (HEA) BACE inhibitors is described. Variation of the P1′ region provided selectivity over Cat-D with a series of 2,2-dioxo-isothiochromanes and optimi
