12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoic acid methyl ester

Base Information

• Chemical Name: 12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoic acid methyl ester
• CAS No.: 426210-64-2
• Molecular Formula: C₃₂H₅₆N₂O₆
• Molecular Weight: 564.806
• Mol file: 426210-64-2.mol

Synonyms:12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoic acid methyl ester

Chemical Property of 12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoic acid methyl ester

There total 2 articles about 12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methyl 12-bromododecanoate (26825-95-6) + 7-benzyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (94605-71-7) → 12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoic acid methyl ester (426210-64-2)

Guidance literature:

With sodium carbonate; potassium iodide; In various solvent(s); for 24h; Heating;

DOI:10.1002/jhet.5570380623

Reference yield:

12-bromododecanoic acid (73367-80-3) → 12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoic acid methyl ester (426210-64-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / concd. H₂SO₄ / 24 h / Heating

2: 91 percent / Na₂CO₃; KI / various solvent(s) / 24 h / Heating

With sulfuric acid; sodium carbonate; potassium iodide; In various solvent(s);

DOI:10.1002/jhet.5570380623

Reference yield: 98.0%

12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoic acid methyl ester (426210-64-2) → 12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoic acid (426210-66-4)

Guidance literature:

With sodium hydroxide; for 18h; Heating;

DOI:10.1039/b005436o

upstream raw materials:

methyl 12-bromododecanoate

7-benzyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

12-bromododecanoic acid

Downstream raw materials:

12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoic acid

12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-1-{16-[12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoyl]-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl}-dodecan-1-one