2-(5-methyl-2-phenyl-oxazol-4-yl)-ethylammonium mesylate

Base Information

• Chemical Name: 2-(5-methyl-2-phenyl-oxazol-4-yl)-ethylammonium mesylate
• CAS No.: 910795-68-5
• Molecular Formula: CH₄O₃S*C₁₂H₁₄N₂O
• Molecular Weight: 298.363
• Mol file: 910795-68-5.mol

Synonyms:2-(5-methyl-2-phenyl-oxazol-4-yl)-ethylammonium mesylate

Chemical Property of 2-(5-methyl-2-phenyl-oxazol-4-yl)-ethylammonium mesylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(5-methyl-2-phenyl-oxazol-4-yl)-ethylammonium mesylate

There total 2 articles about 2-(5-methyl-2-phenyl-oxazol-4-yl)-ethylammonium mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonic acid (75-75-2,98527-29-8) + 2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)acetonitrile (524959-64-6) → 2-(5-methyl-2-phenyl-oxazol-4-yl)-ethylammonium mesylate (910795-68-5)

Guidance literature:

2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)acetonitrile; With hydrogen; sodium formate; Raney cobalt (Johnson Matthey 8B₀₀₂₂); In ethanol; at 70 ℃; for 4h; under 7500.75 Torr;

methanesulfonic acid; In ethanol; Product distribution / selectivity;

Reference yield:

2-(2-phenyl-5-methyloxazole-4-yl)ethyl methanesulfonate (227029-27-8) → 2-(5-methyl-2-phenyl-oxazol-4-yl)-ethylammonium mesylate (910795-68-5)

Guidance literature:

With ammonia; In methanol; at -20 - 80 ℃; for 2 - 3h; under 7500.75 Torr; Product distribution / selectivity;

Reference yield:

methanesulfonic acid (75-75-2,98527-29-8) + 2-(5-methyl-2-phenyl-oxazol-4-yl)-ethylammonium mesylate (910795-68-5) + (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile (207557-35-5) → (S)-1-{[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethylamino]-acetyl}-pyrrolidine-2-carbonitrile mesylate (910795-71-0)

Guidance literature:

2-(5-methyl-2-phenyl-oxazol-4-yl)-ethylammonium mesylate; With calcium hydroxide; In ISOPROPYLAMIDE; at 25 - 30 ℃; for 0.25 - 1h;

(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile; In ISOPROPYLAMIDE; at 25 - 30 ℃; for 1.25 - 2.5h;

methanesulfonic acid; In dichloromethane; ISOPROPYLAMIDE; water; pH=7.8; Product distribution / selectivity;

upstream raw materials:

2-(2-phenyl-5-methyloxazole-4-yl)ethyl methanesulfonate

methanesulfonic acid

2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)acetonitrile

Downstream raw materials:

(S)-1-{[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethylamino]-acetyl}-pyrrolidine-2-carbonitrile mesylate